2023 World Conference on Lung Cancer (Posters)-EP03.02. EGFR T790M Detection Differences by Original Mutation Types and Detection Samples

EP03.02. EGFR T790M Detection Differences by Original Mutation Types and Detection Samples - PDF(Slides)

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A study conducted at Shanghai Pulmonary Hospital examined the differences in detecting the EGFR T790M mutation based on the original mutation types and detection samples. The study included patients with non-small cell lung cancer (NSCLC) who had EGFR sensitive mutations and developed resistance to targeted therapy. The patients were retrospectively collected from January 2020 to December 2022.<br /><br />All the enrolled patients underwent EGFR re-detection via ARMS-PCR after developing resistance. The study found that the incidence of the T790M mutation varied depending on the sample type and the original mutation type. The sample types included plasma, cytological specimens, biopsy tissue, and pleural effusion.<br /><br />The incidence of the T790M mutation was highest in plasma samples (32.20%), followed by biopsy tissue (31.50%), cytological specimens (48.20%), and pleural effusion (53.00%). However, in some sample types, no T790M mutation was detected. For example, no T790M mutation was detected in tissue samples or in cases where the original mutation type was uncommon.<br /><br />The study also found that patients with uncommon EGFR sensitive mutations had a significantly lower incidence of the T790M mutation after EGFR-TKI treatment compared to patients with the 19del or L858R mutation. As a result, the authors suggest that advanced pleural effusions should be considered as an optional choice for detecting the T790M mutation.<br /><br />Furthermore, due to the high negative rate, blood detection should only be used as a supplementary method in re-detection after target therapy. Overall, understanding the differences in detecting the T790M mutation based on sample types and original mutation types can inform clinical decisions and improve patient outcomes.

Asset Subtitle

Jian Ni

Meta Tag

Speaker Jian Ni

Topic Tumor Biology: Translational Biology - Drug Resistance

Keywords

Shanghai Pulmonary Hospital

EGFR T790M mutation

detection samples

non-small cell lung cancer

targeted therapy

ARMS-PCR

plasma samples

biopsy tissue

cytological specimens

pleural effusion