2023 World Conference on Lung Cancer (Posters)-EP03.03. IS1160 Transposon Mycobacterium Tuberculosis Detection in Lung Cancer - A Preliminary Study

EP03.03. IS1160 Transposon Mycobacterium Tuberculosis Detection in Lung Cancer - A Preliminary Study - PDF(Abstract)

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This study investigates the presence of Mycobacterium tuberculosis (M. Tb) DNA in lung cancer patients and its potential role in lung carcinogenesis. The researchers extracted DNA from histopathology specimens of non-small cell lung cancer (NSCLC) patients and used the end-point PCR method to detect the IS1160 Transposon Tuberculosis. The clinical data of the patients were obtained from medical records. <br /><br />Among the 10 NSCLC patients analyzed, all had advanced stage cancer, with 2 in the early stage and 8 in advanced stages based on the lung cancer staging. Only 2 patients had a previous history of pulmonary TB infection, but M. Tb was not detected in any patients at the time of diagnosis. Interestingly, the IS1160 Transposon Mycobacterium Tuberculosis was detected in one patient with adenocarcinoma, who had no history of TB infection and M. Tb was not found in bronchial washing PCR TB or TB culture.<br /><br />The findings suggest that M. Tb DNA can be detected in lung cancer specimens, but further research is needed to understand its role in lung carcinogenesis. This study highlights the potential link between chronic inflammation and fibrosis caused by tuberculosis and the development of lung cancer. Chronic inflammation and fibrosis have been associated with the development of cancer, and previous studies have shown a correlation between a history of pulmonary TB infection and an increased risk of developing lung cancer.<br /><br />In conclusion, this preliminary study provides evidence of M. Tb DNA detection in lung cancer patients, but further investigation is necessary to determine its significance in lung carcinogenesis. The study sheds light on the potential role of tuberculosis in the development of lung cancer and the need for more research in this area.

Asset Subtitle

Hana Faisal

Meta Tag

Speaker Hana Faisal

Topic Tumor Biology: Translational Biology - IO

Keywords

Mycobacterium tuberculosis DNA

lung cancer patients

lung carcinogenesis

non-small cell lung cancer

end-point PCR method

IS1160 Transposon Tuberculosis

clinical data

pulmonary TB infection

adenocarcinoma

chronic inflammation and fibrosis