2023 World Conference on Lung Cancer (Posters)-EP03.03. The Involvement of Tumor Endothelial Cells in the Regulation of PD-L1 and Tregs in the Immune Microenvironment of Early-stage Lung Adenocarcinoma

EP03.03. The Involvement of Tumor Endothelial Cells in the Regulation of PD-L1 and Tregs in the Immune Microenvironment of Early-stage Lung Adenocarcinoma - PDF(Abstract)

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This presentation explores the involvement of tumor endothelial cells in the regulation of PD-L1 and Tregs in the immune microenvironment of early-stage lung adenocarcinoma. The study aimed to provide a new way to evaluate patient histological subtypes at a single-cell level and analyze the differences between the lepidic and acinar subtypes. Six patients with early-stage lung adenocarcinoma were analyzed using single-cell RNA sequencing. Additionally, a tissue section from a lung adenocarcinoma patient was analyzed using digital spatial profiling. The results showed differences in the microenvironment between the lepidic and acinar subtypes, with FOXP3, a biomarker for Tregs, being expressed highest in normal areas and decreasing as tumors occurred. The expression of FOXP3 gradually increased as the tumor progressed. The expression trend of PD-L1 on endothelial cells was consistent with FOXP3, suggesting that endothelial cells promote the progression of early lung adenocarcinoma by activating Tregs cells and inhibiting the immune response. The findings indicate that endothelial cells could be a potential target for immunotherapy in early-stage lung adenocarcinoma. Overall, this study highlights the importance of considering the role of endothelial cells in the immune microenvironment and provides insights for new therapeutic strategies in lung adenocarcinoma.

Asset Subtitle

Dawei Yang

Meta Tag

Speaker Dawei Yang

Topic Tumor Biology: Translational Biology - IO

Keywords

tumor endothelial cells

regulation

PD-L1

Tregs

immune microenvironment

early-stage lung adenocarcinoma

histological subtypes

single-cell level

lepidic subtype

acinar subtype