2023 World Conference on Lung Cancer (Posters)-EP03.05. Aberrant Methylation of ZNF577 As a Potential Prognostic Biomarker for Lung Adenocarcinoma

EP03.05. Aberrant Methylation of ZNF577 As a Potential Prognostic Biomarker for Lung Adenocarcinoma - PDF(Slides)

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The study titled "Aberrant Methylation of ZNF577 as a Potential Prognostic Biomarker for Lung Adenocarcinoma" investigates the role of ZNF577 gene in lung adenocarcinoma. The researchers analyzed the methylation and expression levels of ZNF577 in tumor tissues and correlated them with clinical characteristics and patient survival.<br /><br />ZNF proteins play a role in cancer progression through their interactions with miRNAs and signaling cascades. The researchers hypothesized that aberrant methylation of ZNF577 may contribute to the malignant features of lung adenocarcinoma.<br /><br />The study included 73 patients with lung adenocarcinoma. The expression level of ZNF577 mRNA was found to be significantly higher in females, non-smokers, and earlier-stage samples. The patients with high ZNF577 mRNA expression showed better overall and disease-free survival rates compared to those with low expression.<br /><br />The researchers also analyzed the methylation levels of ZNF577 and found that they were significantly higher in lung adenocarcinoma tissues. Lepidic samples had lower methylation levels compared to papillary samples. The methylation levels were also found to be higher in samples with vascular invasion.<br /><br />The study concludes that hypermethylation and low gene expression of ZNF577 may contribute to the malignant features and worse prognosis of patients with lung adenocarcinoma. The findings suggest that ZNF577 methylation and expression levels can potentially serve as prognostic biomarkers for lung adenocarcinoma.<br /><br />This research provides valuable insights into the role of ZNF577 in lung adenocarcinoma and highlights its potential as a prognostic biomarker. Further studies are needed to validate these findings and explore the underlying mechanisms of ZNF577 in lung adenocarcinoma progression.

Asset Subtitle

Batkhishig Munkhjargal

Meta Tag

Speaker Batkhishig Munkhjargal

Topic Tumor Biology: Translational Biology - Omics and New Technologies

Keywords

ZNF577

methylation

prognostic biomarker

lung adenocarcinoma

gene expression

clinical characteristics

patient survival

miRNAs

signaling cascades

hypermethylation