2023 World Conference on Lung Cancer (Posters)-EP03.05. Identification of Oncogenic Non-coding Regions Inducing the ANKZF1 Expression in Lung Cancer by a Multi-omics Website Omics3D

EP03.05. Identification of Oncogenic Non-coding Regions Inducing the ANKZF1 Expression in Lung Cancer by a Multi-omics Website Omics3D - PDF(Abstract)

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The study presented in this session of the WCLC 2023 conference focused on the identification of oncogenic non-coding regions that induce the expression of ANKZF1 in lung cancer. The authors developed a website called Omics3D, which contains a comprehensive multi-omics database generated from seven different cancer types. Using this database, they identified ANKZF1 as being induced in lung cancer and confirmed its high expression level in lung cancer patients. They also found that the expression of ANKZF1 is negatively associated with the survival rate of lung cancer patients. Mechanistically, they identified ANKZF1-associated chromatin loops that were enriched in lung cancer and bridged distant enhancers to the ANKZF1 promoter. These chromatin loops were confirmed by the binding peaks of the chromatin loop structure anchor protein CTCF. The authors suggested that the increased expression of ANKZF1 may be due to the increased binding of these distant enhancers, rather than the promoter's enhancer complex. They also found that the open chromatin regions were enhanced in lung cancer, as indicated by the ATAC-Seq peaks. Further analysis revealed that the top transcription factor regulating chromatin loop remodeling in these functional non-coding regions is ETS1. The authors concluded that by targeting the regulators of the ANKZF1-associated non-coding regions, potential therapeutic targets for treating lung cancer could be identified. Overall, this study highlights the importance of non-coding regions in lung cancer development and offers insights into potential therapeutic strategies.

Asset Subtitle

Chen Lian

Meta Tag

Speaker Chen Lian

Topic Tumor Biology: Translational Biology - Omics and New Technologies

Keywords

oncogenic non-coding regions

ANKZF1 expression

lung cancer

Omics3D website

chromatin loops

CTCF binding peaks

distant enhancers

open chromatin regions

transcription factor

therapeutic targets