2023 World Conference on Lung Cancer (Posters)-EP04.01. Double Blind Evaluation of Circulating Cancer Associated Macrophage Like (CAML) Cells for Detection of Cancer in Pulmonary Nodules

EP04.01. Double Blind Evaluation of Circulating Cancer Associated Macrophage Like (CAML) Cells for Detection of Cancer in Pulmonary Nodules - PDF(Slides)

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A multicenter study was conducted to evaluate the use of circulating cancer-associated macrophage-like (CAML) cells for the detection of cancer in indeterminate pulmonary nodules. The study enrolled patients with nodules ranging in size from 8mm to 3cm who had no prior diagnosis of cancer. Blood samples were obtained from the patients, and CAMLs were detected using a filter-based system. The primary objective was to determine the positive predictive value (PPV), negative predictive value (NPV), sensitivity, and specificity of CAMLs at the initial screening.<br /><br />A total of 203 patients were enrolled in the study, and 200 had samples sent for CAML detection and underwent diagnostic procedures. CAMLs were detected in 45% of patients. However, there was no correlation between the size of CAMLs and the risk of malignancy. The presence or absence of CAMLs did not enhance the predictive value of nodule size for detecting malignancy. The study concluded that CAMLs are neither sensitive nor specific for the presence of malignancy in indeterminate pulmonary nodules.<br /><br />The study also compared CAML detection with other clinical and radiologic features to determine if there was any correlation. Additional analyses are still underway to further investigate this.<br /><br />The results of the study suggest that CAMLs may not be an effective tool for detecting cancer in indeterminate pulmonary nodules. However, the study acknowledges that more research is needed to fully understand the potential correlation between CAMLs and other clinical or radiologic features.<br /><br />The study provides valuable insights into the use of CAMLs for cancer detection in pulmonary nodules and highlights the need for further investigation in this area.

Asset Subtitle

Martin Edelman

Meta Tag

Speaker Martin Edelman

Topic Screening & Early Detection: Biomarkers/Imaging Technology

Keywords

multicenter study

CAML cells

cancer detection

pulmonary nodules

predictive value

nodule size

malignancy

correlation

clinical features

radiologic features