2023 World Conference on Lung Cancer (Posters)-EP04.01. The PneuVision Test Detects Both Lung Squamous Cell Carcinoma and Adenocarcinoma from Cells in Sputum

EP04.01. The PneuVision Test Detects Both Lung Squamous Cell Carcinoma and Adenocarcinoma from Cells in Sputum - PDF(Slides)

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The PneuVision Sputum Test is a diagnostic tool that uses Cell-CT Analysis to analyze cells in a true 3D format, providing high-resolution morphometry measurements. This test is particularly useful in detecting abnormal features in cells, which are then diagnosed using VisionGate's digital pathology workstation, CellGazer. The test has been shown to have a high sensitivity and specificity, with a detection rate of over 90% for abnormal cells. The test can be tailored to detect different types of lung cancer, such as squamous cell carcinoma and adenocarcinoma, with different levels of sensitivity based on the number of normal bronchial epithelial cells present.<br /><br />In order to evaluate the sensitivity of the PneuVision Sputum Test, sputum samples were collected from patients with biopsy-confirmed squamous cell carcinoma and adenocarcinoma. The Cell-CT analysis was then normalized using the enumeration of normal bronchial epithelial cells. The abnormal cells detected by the Cell-CT were confirmed by expert cytologists. The sensitivity of the test was then analyzed based on the number of normal cells present.<br /><br />The results showed that the sensitivity of the test varied depending on the type of cancer. For a given sensitivity level, a larger number of cells needed to be processed for adenocarcinoma compared to squamous cell carcinoma. For example, to achieve a 90% sensitivity rate for squamous cell carcinoma, at least 1000 normal bronchial epithelial cells needed to be processed. With the same number of cells, the sensitivity for adenocarcinoma would be 83%.<br /><br />Overall, the PneuVision Sputum Test has demonstrated high sensitivity in detecting both squamous cell carcinoma and adenocarcinoma. The sensitivity of the test can be adjusted based on the number of normal cells processed, and it is more sensitive to squamous cell carcinoma than adenocarcinoma. This test shows promise as a valuable tool in the early detection of lung cancer.

Asset Subtitle

Michael Meyer

Meta Tag

Speaker Michael Meyer

Topic Screening & Early Detection: Biomarkers/Imaging Technology

Keywords

PneuVision Sputum Test

Cell-CT Analysis

high-resolution morphometry measurements

VisionGate's digital pathology workstation

CellGazer

lung cancer detection

squamous cell carcinoma

adenocarcinoma

sensitivity analysis

early detection of lung cancer