2023 World Conference on Lung Cancer (Posters)-EP04.05. Incidentally-Detected Lung Cancer in Persons Too Young or Too Old for Lung Cancer Screening.

EP04.05. Incidentally-Detected Lung Cancer in Persons Too Young or Too Old for Lung Cancer Screening. - PDF(Abstract)

Pdf Summary

This study aimed to evaluate the diagnosis and survival outcomes of incidentally-detected lung cancer in individuals who are too young or too old for lung cancer screening. The researchers compared lung cancer diagnosis and overall survival between low-dose computer tomographic (LDCT) screening participants and those enrolled in a lung nodule program (LNP) for individuals ineligible for LDCT screening.<br /><br />The study included a cohort of 9,607 LDCT recipients, 3,624 young LNP enrollees aged 35 to 50 years, and 2,502 elderly LNP enrollees aged 80 years or older. The characteristics of the cohorts, such as age, race, insurance status, and active cigarette use, were compared. Lung cancer was diagnosed in 3.19% of LDCT participants, 1.05% of young LNP enrollees, and 6.79% of elderly LNP enrollees. In the young LNP cohort, the cumulative incidence of lung cancer diagnosis was similar to LDCT participants with Lung-RADS scores of 1 and 2. In the elderly LNP cohort, the cumulative incidence exceeded Lung-RADS 3 but was less than Lung-RADS 4. The clinical stage of lung cancer also differed across the groups, with higher proportions of early-stage cancer in LDCT participants compared to the LNP cohorts.<br /><br />Overall survival was significantly worse in the LNP cohorts, particularly in the elderly group, with a median survival of only 1.99 years compared to not being reached in the LDCT and young LNP cohorts.<br /><br />These findings suggest that although LNP may expand access to early lung cancer detection for individuals ineligible for LDCT screening, the survival outcomes are worse, especially in the elderly. Therefore, there appears to be a modest benefit of early detection in such patients. This study highlights the importance of considering age eligibility and appropriate screening methods to improve early lung cancer detection and survival outcomes.

Asset Subtitle

Raymond Osarogiagbon

Meta Tag

Speaker Raymond Osarogiagbon

Topic Screening & Early Detection: Program Design

Keywords

incidentally-detected lung cancer

lung cancer screening

diagnosis

survival outcomes

low-dose computer tomographic

LDCT screening participants

lung nodule program

LNP

cohort

age eligibility