2023 World Conference on Lung Cancer (Posters)-EP05.01. An Analysis of Lymph Node Metastasis Patterns in Surgical Cases of Non-small-Cell Lung Cancer

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This study analyzed the patterns of lymph node metastasis in surgical cases of non-small-cell lung cancer (NSCLC), with a focus on examining the correlation between lymph node metastasis and prognosis according to the new TNM classification scheme proposed by the IASLC. The study included 441 surgical cases of NSCLC, and the results showed that the new classification scheme may more accurately reflect the prognosis and could potentially contribute to the development of individualized treatment strategies.<br /><br />The study found that skip metastasis, where cancer spreads to distant lymph nodes without involving intervening nodes, accounted for a small percentage of cases. Most cases remained within the zone of selective lymph node dissection. Only one case showed skip metastasis to a lymph node outside of the standard dissection zone.<br /><br />The analysis of patient characteristics revealed that the average age of the patients was 70.2, with a higher percentage of male patients (63.3%). The primary site of the tumor was predominantly in the right upper lobe (36.5%). Adenocarcinoma was the most common histology (70.7%), followed by squamous cell carcinoma (22.9%).<br /><br />The study also assessed the relationship between lymph node metastasis and prognosis. The 3-year recurrence-free survival rate was highest in patients with no lymph node metastasis (84.4%) and lowest in patients with N2b metastasis (18.2%). Patients with skip N2 metastasis (N2a1 and N2a2) had a better trend compared to those with multiple station N2 metastasis.<br /><br />The study concluded that the new N-classification scheme may provide a more accurate assessment of prognosis and could help guide individualized treatment strategies for NSCLC. The findings highlighted the significance of skip metastasis and its impact on prognosis, suggesting that it may have a similar pathogenesis and prognosis as N1 metastasis. Overall, this analysis contributes to our understanding of lymph node metastasis patterns in NSCLC and their implications for patient management.

Asset Subtitle

Miyuki Abe

Meta Tag

Speaker Miyuki Abe

Topic Pulmonology & Staging

Keywords

lymph node metastasis

NSCLC

TNM classification

prognosis

individualized treatment

skip metastasis

selective lymph node dissection

adenocarcinoma

squamous cell carcinoma

patient management