2023 World Conference on Lung Cancer (Posters)-EP05.01. Lung Cancers Diagnosed in a Retrospective Cohort of Lung Nodule Patients in Singapore

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A retrospective study conducted in Singapore examined the lung cancers diagnosed in patients with lung nodules. The study aimed to evaluate the lung cancers diagnosed through the nodule pathway at a tertiary hospital in Singapore. Data from 170 patients seen in the pulmonary medicine clinic between 2016 and 2017 were analyzed. The results showed that 13.5% of the patients were diagnosed with lung cancer. Patient factors associated with malignancy included male gender, smoking status, increasing absolute FEV1, and increasing percentage predicted FEV1.<br /><br />PET-CT scans were carried out on all patients later diagnosed with lung cancer, while none of those without lung cancer received this scan. Histological sampling was performed on 8.8% of patients without lung cancer. The most common histological sampling method for lung cancer was radiologically-guided percutaneous biopsy.<br /><br />The majority of lung cancers were diagnosed as invasive adenocarcinoma and at clinical stage 1. Most patients with lung cancer received curative-intent treatment, with surgical resection being the most common treatment modality. During the follow-up period, 39.1% of patients experienced recurrence or progression of the disease.<br /><br />The study concluded that most lung cancers diagnosed through the nodule pathway were detected at an early stage, likely due to the selection criteria. The findings of this study provide valuable insights into the diagnosis and treatment outcomes of patients evaluated through the lung nodule pathway in Singapore. Further research is needed to improve outcomes in this pathway.<br /><br />Overall, lung cancer remains a significant cause of cancer-related death globally, and there is a high prevalence of lung cancer in Singapore and Asia, even among never smokers. Despite advancements in lung cancer treatments, the five-year survival rate for lung cancer is still low, highlighting the importance of early detection and improved management strategies.

Asset Subtitle

Mamta Ruparel

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Speaker Mamta Ruparel

Topic Pulmonology & Staging

Keywords

retrospective study

Singapore

lung cancers

lung nodules

tertiary hospital

pulmonary medicine clinic

PET-CT scans

histological sampling

invasive adenocarcinoma

curative-intent treatment