2023 World Conference on Lung Cancer (Posters)-EP06.03. Clinical Study to Molecularly Profile Filipino Lung Adenocarcinoma

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A clinical study conducted in the Philippines aimed to determine the molecular profile of Filipino patients with lung adenocarcinoma, a common type of lung cancer. The study involved 26 patients who were diagnosed with lung adenocarcinoma between June 2018 and June 2021. Tumor tissue samples and blood samples were collected from the patients for molecular profiling.<br /><br />The results of the study showed that the majority of the patients were male and the median age was 57.5 years old. Fifty-four percent of the patients were in stage IV lung cancer and were never smokers. Molecular profiling of the tumor samples revealed that 50% of the cases tested exhibited mutations in the Epidermal Growth Factor (EGFR) gene, while 18.2% were positive for the Anaplastic Lymphoma Kinase (ALK) mutation. Circulating tumor cell counts (CTC) were generally low, with fewer than 5 CTCs per 7.5 mL of blood detected in all samples analyzed.<br /><br />The study also examined the expression of three cancer markers, CD133, KRT19, and MUC1, and found that they were upregulated in approximately half of the samples. Furthermore, some samples showed upregulation of multiple cancer markers.<br /><br />The findings of this study suggest that Filipino patients with lung adenocarcinoma have a diverse molecular profile, confirming the presence of reported EGFR and ALK mutations. The low CTC counts in advanced stage patients indicate the need for further investigation into the role of CTCs in this type of cancer. The upregulation of cancer markers may have diagnostic and therapeutic implications.<br /><br />Overall, molecular profiling provides valuable data for the selection of appropriate lung cancer therapy and monitoring of treatment response. The study was funded by the Commission on Higher Education - Philippine-California Advanced Research Institutes (CHED-PCARI) and involved collaboration with various research institutions and individuals.

Asset Subtitle

Francisco Heralde

Meta Tag

Speaker Francisco Heralde

Topic Pathology & Biomarkers: Genetic Biomarkers

Keywords

clinical study

molecular profile

lung adenocarcinoma

tumor samples

EGFR gene

ALK mutation

circulating tumor cells

cancer markers

diagnostic implications

lung cancer therapy