2023 World Conference on Lung Cancer (Posters)-EP06.03. Genomic Alterations in Advanced Lung Cancer Patients Compared via CGP and Hotspot Panel Test in a Bangladeshi Tertiary Hospital

EP06.03. Genomic Alterations in Advanced Lung Cancer Patients Compared via CGP and Hotspot Panel Test in a Bangladeshi Tertiary Hospital - PDF(Abstract)

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This study aimed to compare the frequency of genomic alterations in advanced lung cancer patients using two next-generation sequencing (NGS) methods, Comprehensive Genomic Profiling (CGP) and Hotspot panel, in a tertiary hospital in Bangladesh. The data were collected from test reports of 62 advanced lung cancer patients who underwent NGS testing between November 2019 and December 2022. CGP was performed on 21 patients, while 41 patients were tested using the Hotspot panel. CGP identified more actionable genomic alterations compared to the Hotspot panel test. The probability of identifying no genomic alterations was higher in the Hotspot panel test than in CGP. The study found that the probability of detecting actionable genomic alterations is high with CGP compared to the Hotspot panel. CGP can also identify novel or uncommon genomic alterations that may have clinical significance. While CGP is more expensive, it should be preferred if the patient can afford it. The findings from CGP may have important implications for patient management and personalized treatment approaches in Bangladesh. However, larger studies are needed to confirm these findings and establish guidelines for genomic testing in advanced lung cancer patients in Bangladesh.

Asset Subtitle

Qamruzzaman Chowdhury

Meta Tag

Speaker Qamruzzaman Chowdhury

Topic Pathology & Biomarkers: Genetic Biomarkers

Keywords

genomic alterations

next-generation sequencing

Comprehensive Genomic Profiling

Hotspot panel

advanced lung cancer

tertiary hospital

Bangladesh

actionable genomic alterations

novel genomic alterations

patient management