2023 World Conference on Lung Cancer (Posters)-EP06.05. Distant Metastasis Pattern and Baseline Clinicopathological Features from a Real-World KRAS G12C Mutant Cohort of Advanced NSCLC Patients

EP06.05. Distant Metastasis Pattern and Baseline Clinicopathological Features from a Real-World KRAS G12C Mutant Cohort of Advanced NSCLC Patients - PDF(Abstract)

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This study aimed to investigate the clinicopathological features and metastasis patterns of advanced non-small cell lung cancer (NSCLC) patients with KRAS G12C mutation. The researchers conducted a retrospective analysis of newly diagnosed patients with stage IIIC-IV NSCLC who underwent next-generation sequencing (NGS) testing between September 2022 and March 2023. A total of 62 patients were included in the study, with adenocarcinoma being the most frequent histology (90.3%). The results showed that 38.7% of patients had KRAS mutations, with the most common mutation being G12C (37.5%).<br /><br />The researchers found that KRAS mutant patients were more frequently current/former smokers compared to KRAS wild-type patients. However, there was no significant difference in PD-L1 expression levels between the two groups. No concomitant oncogenic driver mutations were observed in the KRAS mutant cohort.<br /><br />In terms of metastasis patterns, the study found that G12C mutant patients had a higher incidence of brain metastases compared to non-G12C patients (66.6% vs 13.3%). They also had a greater number of metastasis sites at the time of diagnosis, particularly in the brain. However, there was no significant difference in liver metastasis distribution between the two groups.<br /><br />Overall, the findings of this study suggest that KRAS mutant patients with NSCLC represent a highly heterogeneous population. The G12C subgroup, in particular, showed a distinct metastasis pattern with a higher incidence of brain metastases. These results highlight the need for better characterization of KRAS mutant patients in order to tailor treatment strategies.

Asset Subtitle

Anna Cecilia Bettini

Meta Tag

Speaker Anna Cecilia Bettini

Topic Pathology & Biomarkers

Keywords

clinicopathological features

metastasis patterns

NSCLC

KRAS G12C mutation

retrospective analysis

adenocarcinoma

PD-L1 expression levels

oncogenic driver mutations

brain metastases

treatment strategies