2023 World Conference on Lung Cancer (Posters)-EP06.05. Non Small Cell Lung Cancer Associated to Dipnech: A Clinico-Pathological Analysis of 32 Cases

EP06.05. Non Small Cell Lung Cancer Associated to Dipnech: A Clinico-Pathological Analysis of 32 Cases - PDF(Abstract)

Pdf Summary

This study provides a clinical and pathological analysis of 32 cases of non-small cell lung cancer (NSCLC) associated with Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH). DIPNECH is a condition that has been suggested to be a precursor to lung carcinoids, but there is limited data on its association with NSCLC. The authors retrospectively analyzed their institutional database of surgically-treated NSCLC patients and identified 32 cases (2.5%) with an incidental diagnosis of DIPNECH. They collected clinical, functional, radiological, and histological data and analyzed long-term results.<br /><br />The study found that the majority of patients with NSCLC associated with DIPNECH were female (26/81%) with a mean age of 70 years. Lung function showed an obstructive pattern with irreversible airflow obstruction in 37.5% of patients, but only 3 were active smokers. Symptoms such as non-productive cough and wheezing were observed in 8 patients. CT scans revealed bilateral multiple pulmonary nodules, air-trapping, pulmonary emphysema, mucus plugging, pulmonary fibrosis, and bronchiectasis in some patients.<br /><br />Surgery was the primary treatment approach, with lobectomy being the most common procedure. Pathological analysis showed that the most frequent histology was adenocarcinoma, followed by squamous cell carcinoma and large-cell carcinoma. Some cases also showed coexistence with DIPNECH and typical carcinoid. Positive staining for neuroendocrine markers was observed in a subset of cases.<br /><br />Overall, the study suggests that DIPNECH may be associated with a low but significant percentage of NSCLC cases, particularly adenocarcinomas. Despite the small number of cases, patients with NSCLC associated with DIPNECH had a favorable prognosis and some specific clinical manifestations. The authors highlight the need for further research to investigate this topic due to the lack of available data.

Asset Subtitle

Filippo Lococo

Meta Tag

Speaker Filippo Lococo

Topic Pathology & Biomarkers

Keywords

non-small cell lung cancer

NSCLC

Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia

DIPNECH

lung carcinoids

clinical analysis

pathological analysis

surgically-treated NSCLC patients

lobectomy

adenocarcinoma