2023 World Conference on Lung Cancer (Posters)-EP06.05. STAS and Expression of EMT-markers in Surgically Resected Lung Pleomorphic Carcinomas

EP06.05. STAS and Expression of EMT-markers in Surgically Resected Lung Pleomorphic Carcinomas - PDF(Slides)

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This study aimed to determine the occurrence of tumor spread through air spaces (STAS) in pleomorphic lung carcinomas and to investigate whether the expression of epithelial-mesenchymal transition (EMT) markers is associated with STAS and overall survival (OS). The study analyzed 99 patients with pleomorphic carcinoma who were operated on and diagnosed between 2000 and 2019. The researchers conducted morphological analysis, immunohistochemical study of E-cadherin and vimentin expression, and statistical analysis of clinical and pathological data.<br /><br />The results showed that STAS was found in approximately 39% of the patients. E-cadherin expression was stronger and more frequent in the epithelial component compared to the sarcomatous component, while vimentin expression was higher in the sarcomatous component. The intermediate group (EMT markers expression in both components) had a higher frequency of STAS compared to the other groups. STAS was found to be a prognostic factor for disease-free survival (DFS) but not for overall survival (OS) in univariate analysis.<br /><br />The study also revealed that the expression of vimentin and E-cadherin, as well as the EMT phenotype, were not associated with OS and DFS in univariate analysis. However, in multivariate analysis, the intermediate phenotype was predictive of better DFS compared to the epithelial phenotype. Patients with STAS and the mesenchymal phenotype had worse OS and DFS compared to those without STAS. However, it is important to note that the study groups were small.<br /><br />In conclusion, co-expression of E-cadherin and vimentin in pleomorphic lung carcinomas is associated with increased STAS frequency. The mesenchymal immunophenotype may serve as a negative prognostic factor in the subgroup of patients with STAS.

Asset Subtitle

Renata Langfort

Meta Tag

Speaker Renata Langfort

Topic Pathology & Biomarkers

Keywords

tumor spread through air spaces

pleomorphic lung carcinomas

epithelial-mesenchymal transition markers

STAS

overall survival

morphological analysis

immunohistochemical study

E-cadherin expression

vimentin expression

disease-free survival