2023 World Conference on Lung Cancer (Posters)-EP06.05. Subpleural Cystic Mesenchymal Neoplasm with Endometrial-type Stromal Proliferation: A Report of 3 Cases

EP06.05. Subpleural Cystic Mesenchymal Neoplasm with Endometrial-type Stromal Proliferation: A Report of 3 Cases - PDF(Abstract)

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This is a case report presentation titled "Subpleural Cystic Mesenchymal Neoplasm with Endometrial-type Stromal Proliferation: A Report of 3 Cases" presented at the WCLC 2023 conference. The presentation discusses three cases of rare tumors involving the endometrial stromal and related tissues. These tumors, known as Endometrial Stromal and Related Tumors (EST), are uncommon and most commonly occur in peri-menopausal women.<br /><br />The tumors in the cases presented were cystic, well-demarcated, and located in the subpleural region of the lungs. The tumors were characterized by multilocular cystic spaces lined by non-ciliated epithelial cells, infiltrated and expanded stroma, and small spindle cells. The surface epithelial cells were positive for CK7 and TTF-1, while the stromal cells were positive for ER/PR or PR, CD10, desmin or caldesmon, and negative for CK7, PAX-8, and PEComa markers. Molecular testing did not reveal any specific genetic alterations associated with these tumors.<br /><br />The presentation highlights that the stromal cells resemble low-grade endometrial stromal sarcoma, while the TTF-1 positive cells are likely entrapped pneumocytes. The ER/PR and CD10 positivity suggest a gynecologic tract origin. The differential diagnosis includes endometriosis, metastatic cellular leiomyoma, immature teratoma, and pulmonary hamartoma with stromal overgrowth. However, further molecular studies and long-term clinical follow-up are needed to fully understand these tumors.<br /><br />In summary, this presentation describes three cases of subpleural cystic neoplasms with endometrial-type stromal proliferation. These tumors have unique histological and molecular characteristics that differentiate them from other pulmonary neoplasms. Further research is required to gain a better understanding of these rare tumors.

Asset Subtitle

Peter Illei

Meta Tag

Speaker Peter Illei

Topic Pathology & Biomarkers

Keywords

Subpleural Cystic Mesenchymal Neoplasm

Endometrial-type Stromal Proliferation

Endometrial Stromal and Related Tumors

Rare Tumors

Peri-menopausal Women

Lung Tumors

Cystic Neoplasms

Stromal Sarcoma

TTF-1 Positive Cells

Gynecologic Tract Origin