2023 World Conference on Lung Cancer (Posters)-EP06.06. Cancer-Associated Fibroblasts and Estrogen Receptor Beta in Lung Cancer with Idiopathic Pulmonary Fibrosis

EP06.06. Cancer-Associated Fibroblasts and Estrogen Receptor Beta in Lung Cancer with Idiopathic Pulmonary Fibrosis - PDF(Abstract)

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This study investigated the relationship between cancer-associated fibroblasts (CAFs) and estrogen receptor (ER) in lung cancer with idiopathic pulmonary fibrosis (IPF). It is known that CAFs within the tumor microenvironment are associated with immunosuppression and prognosis in lung cancer. IPF is also associated with an increased risk of lung cancer and poor prognosis. The researchers focused on transforming growth factor (TGF) β, vascular endothelial growth factor (VEGF) receptor, S100A4, and ER β. They evaluated 19 lung cancer samples with IPF using immunohistochemistry (IHC) staining and compared the expression of these markers in normal lung, fibrosis, and cancer areas. They also compared the expression in early stage (stage I) and advanced stage (II-IV) lung cancer.<br /><br />The results showed that TGF β and ER β did not have significantly different expression between the different areas. However, the expression of VEGF receptor and S100A4 in fibrosis was significantly higher than in the other two areas. In terms of tumor progression, the expression of TGF β, S100A4, and ER β was higher in advanced stage lung cancer compared to early stage.<br /><br />Based on these findings, it was suggested that TGF β and ER β may regulate each other in lung cancer with IPF. However, their expression was higher in advanced lung cancer. This study provides insights into the role of CAFs and ER in the pathogenesis and progression of lung cancer with IPF.<br /><br />In conclusion, this research focused on understanding the relationship between CAFs and ER in lung cancer with IPF. The study found that the expression of VEGF receptor and S100A4 is higher in fibrosis areas, while the expression of TGF β, S100A4, and ER β is higher in advanced stage lung cancer. These findings contribute to our knowledge of the molecular pathways and biomarkers associated with lung cancer with IPF.

Asset Subtitle

Eiji Nakajima

Meta Tag

Speaker Eiji Nakajima

Topic Pathology & Biomarkers: Prognostic Biomarkers

Keywords

cancer-associated fibroblasts

estrogen receptor

lung cancer

idiopathic pulmonary fibrosis

tumor microenvironment

immunosuppression

prognosis

transforming growth factor

VEGF receptor

S100A4