2023 World Conference on Lung Cancer (Posters)-EP06.06. Clinical Significance of the Presence of MECA-79-Positive Tumor Cells in Pathological Stage IA Invasive Adenocarcinoma of the Lung

EP06.06. Clinical Significance of the Presence of MECA-79-Positive Tumor Cells in Pathological Stage IA Invasive Adenocarcinoma of the Lung - PDF(Abstract)

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This study aimed to investigate the clinical significance of MECA-79-positive tumor cells in patients with pathological stage IA invasive adenocarcinoma of the lung. The study included 195 patients who underwent complete resection with lobectomy for stage IA lung adenocarcinoma. The association between various patient characteristics and recurrence-free survival was assessed using multivariate Cox proportional hazards model. The expression of MECA-79 in lung adenocarcinoma cell lines was also evaluated.<br /><br />The results showed that 9.7% of the patients experienced postoperative recurrence. Patients with MECA-79-positive tumor cells had worse 5-year recurrence-free survival compared to those without MECA-79-positive cells. The presence of MECA-79-positive tumor cells, spread through air spaces, and age were identified as independent risk factors for recurrence-free survival. Furthermore, the expression of MECA-79 was detected in PC-9 cell lines but not in A549 cell lines.<br /><br />Based on these findings, it was concluded that the presence of MECA-79-positive tumor cells may be associated with postoperative recurrence in patients with resected stage IA lung adenocarcinoma. The study highlights the importance of considering MECA-79 expression as a potential prognostic biomarker in this patient population. This research was previously presented at the 102nd Annual Meeting of the American Association for Thoracic Surgery.

Asset Subtitle

Tomohito Saito

Meta Tag

Speaker Tomohito Saito

Topic Pathology & Biomarkers: Prognostic Biomarkers

Keywords

MECA-79-positive tumor cells

clinical significance

pathological stage IA invasive adenocarcinoma

lung

adenocarcinoma

recurrence-free survival

independent risk factors

PC-9 cell lines

A549 cell lines

prognostic biomarker