2023 World Conference on Lung Cancer (Posters)-EP06.06. Epigenetic Silencing of MYO1E in a US Veterans Cohort with Lung Adenocarcinoma and the Effect on Overall Survival

EP06.06. Epigenetic Silencing of MYO1E in a US Veterans Cohort with Lung Adenocarcinoma and the Effect on Overall Survival - PDF(Abstract)

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This study investigated the epigenetic silencing of MYO1E in a cohort of US veterans with lung adenocarcinoma and its effect on overall survival. The researchers conducted a retrospective cohort study including both veterans and civilians with biopsy-proven lung adenocarcinoma. DNA methylation and RNA expression levels of MYO1E were analyzed using methylation-on-beads and qPCR techniques, respectively. The study included a total of 91 patients, with 27 veterans and 64 civilians.<br /><br />The results showed that veterans had greater tobacco exposure, a higher proportion of males, a greater proportion of stage I disease, and a higher proportion of African American patients compared to civilians. In the MYO1E high DNA methylation group, survival was significantly longer compared to the low methylation group. However, there was no significant difference in survival based on RNA expression levels. <br /><br />After adjusting for various factors including age, veteran/civilian status, gender, race, pack-year tobacco use, and stage, the study found that DNA methylation of MYO1E was significantly associated with mortality risk. The absence of MYO1E DNA methylation on tumor tissue may drive biologic aggressiveness and decreased survival in veterans with lung adenocarcinoma.<br /><br />The study suggests that MYO1E DNA methylation could be a potential prognostic biomarker for lung adenocarcinoma in veterans. Further multi-centric studies are needed to validate these findings and explore the use of liquid biopsy as a screening tool for lung cancer in veterans. The identification of biomarkers that can aid in early diagnosis and prognosis of lung adenocarcinoma in veterans is important for improving outcomes in this population.

Asset Subtitle

Kathleen Kennedy

Meta Tag

Speaker Kathleen Kennedy

Topic Pathology & Biomarkers: Prognostic Biomarkers

Keywords

epigenetic silencing

MYO1E

US veterans

lung adenocarcinoma

overall survival

retrospective cohort study

DNA methylation

RNA expression levels

tobacco exposure

biomarker