2023 World Conference on Lung Cancer (Posters)-EP06.06. Epigenetic Silencing of MYO1E in a US Veterans Cohort with Lung Adenocarcinoma and the Effect on Overall Survival

EP06.06. Epigenetic Silencing of MYO1E in a US Veterans Cohort with Lung Adenocarcinoma and the Effect on Overall Survival - PDF(Slides)

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A study conducted at the University of Illinois College of Medicine in Chicago examined the epigenetic silencing of MYO1E gene in a cohort of US veterans with lung adenocarcinoma and its impact on overall survival. The researchers aimed to determine the effect of DNA methylation and RNA expression of MYO1E on mortality in these patients.<br /><br />The study included a retrospective review of 64 civilians and 27 US veterans with a tissue diagnosis of lung adenocarcinoma. The researchers analyzed the DNA methylation and RNA expression levels of MYO1E in the tumor tissues.<br /><br />The results showed that high DNA methylation of MYO1E was associated with longer survival compared to low methylation. However, RNA expression levels of MYO1E did not show a significant difference in survival. The multivariate COX regression analysis, adjusted for various factors, confirmed that DNA methylation of MYO1E was significantly associated with mortality risk.<br /><br />The authors concluded that the degree of MYO1E DNA methylation in tumor tissue may play a role in the aggressiveness and survival of US veterans diagnosed with lung adenocarcinoma. They suggested that prospective, multi-site studies are needed to validate these findings using liquid biopsy and to further investigate the role of MYO1E expression in chemotherapy resistance and immune modulation.<br /><br />In summary, this study found that the DNA methylation status of MYO1E gene is associated with overall survival in US veterans with lung adenocarcinoma. These findings provide new insights into the biology of lung adenocarcinoma and may have implications for prognosis and treatment in this population. Further research is needed to confirm these results and explore potential therapeutic targets.

Asset Subtitle

Kathleen Kennedy

Meta Tag

Speaker Kathleen Kennedy

Topic Pathology & Biomarkers: Prognostic Biomarkers

Keywords

University of Illinois College of Medicine

epigenetic silencing

MYO1E gene

lung adenocarcinoma

overall survival

DNA methylation

RNA expression

mortality risk

chemotherapy resistance

immune modulation