2023 World Conference on Lung Cancer (Posters)-EP07.01. Identifying the Optimal Number of Lymph Node Stations for Improving Survival in Resections for Non-small Cell Lung Cancer

EP07.01. Identifying the Optimal Number of Lymph Node Stations for Improving Survival in Resections for Non-small Cell Lung Cancer - PDF(Abstract)

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This presentation at the WCLC 2023 conference focused on identifying the optimal number of lymph node stations for improving survival in patients who underwent resections for non-small cell lung cancer (NSCLC). The study analyzed data from the Mid-South Quality of Surgical Resection cohort between 2009 and 2021. The researchers examined the association between the number of lymph node stations examined and survival outcomes.<br /><br />The results showed that a minimum of 7 lymph node stations examined was associated with a survival improvement in patients with pathologic stage I NSCLC. However, no clear threshold for the number of lymph node stations was found for patients with more advanced pathologic stage.<br /><br />To determine the optimal number of lymph node stations, the researchers performed cutoff analysis by dichotomizing the number of stations examined at various cutoff points. Cox hazard models were used to calculate hazard ratios for each binary number of lymph node stations, with resections that had more stations sampled than the cutoff point as the referent level. The analysis took into account various factors such as age, sex, histology, clinical stage, extent of resection, and surgical technique.<br /><br />The study included 3554 resections, with 70% of cases being pathologic stage IA/IB[4cm] and 30% being pathologic stage IB[4cm] to IIIA[N2 negative]. The majority of the cohort was White race (78%) and male (54%). The analysis showed a reduction in hazards when 7 lymph node stations were sampled.<br /><br />These findings have implications for future guidelines in the treatment of NSCLC. The optimal number of lymph node stations for improving survival in early-stage NSCLC appears to be 7, but further studies are needed to determine the optimal number for more advanced stages.

Asset Subtitle

Matthew Smeltzer

Meta Tag

Speaker Matthew Smeltzer

Topic Early-Stage NSCLC: Best Practice

Keywords

WCLC 2023 conference

lymph node stations

survival

non-small cell lung cancer

NSCLC

Mid-South Quality of Surgical Resection cohort

pathologic stage

cutoff analysis

hazard ratios

resections