2023 World Conference on Lung Cancer (Posters)-EP07.01. Identifying the Optimal Number of Lymph Node Stations for Improving Survival in Resections for Non-small Cell Lung Cancer

EP07.01. Identifying the Optimal Number of Lymph Node Stations for Improving Survival in Resections for Non-small Cell Lung Cancer - PDF(Slides)

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This study aimed to determine the optimal number of lymph node stations (NLNS) for improving survival in patients undergoing resections for non-small cell lung cancer (NSCLC). The researchers examined first resections for NSCLC in patients without neoadjuvant therapy and with negative margins. Cutoff analysis was performed to identify the optimal NLNS, and hazard ratios (HR) were calculated for each binary NLNS using Cox proportional hazard models.<br /><br />The results showed that a minimum of seven lymph node stations sampled was associated with an improvement in overall survival in patients with less advanced NSCLC. However, in patients with more advanced disease, there was no specific threshold NLNS associated with overall survival.<br /><br />The analysis also revealed that the number of lymph node stations sampled had a significant impact on survival, with a reduction in hazards observed when seven total stations were sampled.<br /><br />The study included a cohort of 3554 eligible resections performed between 2009 and 2021. The majority of patients were White, male, and had commercial insurance or Medicare. Preoperative invasive staging and PET-CT scans were performed in a portion of the patients.<br /><br />Overall, the findings suggest that the thoroughness of nodal examination, specifically the number of lymph node stations sampled, can impact long-term survival in NSCLC patients undergoing resection. The study provides evidence for the importance of sampling at least seven lymph node stations in patients with less advanced disease.<br /><br />This research contributes to the understanding of optimal lymph node examination in NSCLC resections and may help inform future guidelines for the management of this disease.

Asset Subtitle

Matthew Smeltzer

Meta Tag

Speaker Matthew Smeltzer

Topic Early-Stage NSCLC: Best Practice

Keywords

lymph node stations

non-small cell lung cancer

NSCLC

survival

resections

neoadjuvant therapy

negative margins

cutoff analysis

hazard ratios

Cox proportional hazard models