2023 World Conference on Lung Cancer (Posters)-EP07.02. Image-Guided Thermal Ablation of Early-Stage Non-small Cell Lung Cancer; Five-Year Outcome

EP07.02. Image-Guided Thermal Ablation of Early-Stage Non-small Cell Lung Cancer; Five-Year Outcome - PDF(Slides)

Pdf Summary

A study conducted at UCLA assessed the five-year outcome of medically inoperable patients with stage 1 non-small cell lung cancer (NSCLC) who underwent image-guided thermal ablation. The study included 37 patients with single or multiple stage 1 NSCLCs who received ablations during 2015-2016. A total of 101 thermal ablations were performed, including 50 microwave ablations and 51 percutaneous cryoablations.<br /><br />The primary outcomes measured were 5-year overall survival, lung-cancer specific survival, and progression-free survival. The results showed that all ablations were technically successful. However, there were complications, including major pneumothorax requiring hospital admission and one patient mortality. Recurrent disease was identified in 9 out of 101 ablated lesions, on average 23 months following the procedure. The management of recurrence included repeat ablation, chemotherapy/immunotherapy, and stereotactic body radiation therapy (SBRT).<br /><br />The survival measures showed a 5-year overall survival rate of 70.3% and a lung-cancer specific survival rate of 91.9%. The causes of mortality in the study cohort varied, including advanced cancers, respiratory failure, pneumonia, and other comorbidities.<br /><br />The study concludes that image-guided thermal ablation is a safe procedure for patients with stage 1 NSCLC, with excellent cancer-specific and progression-free survival rates. Repeat thermal ablation is also a feasible option for patients with multiple metachronous primary lung cancers. CT-guided thermal ablation is recommended for patients who are not medically inoperable and have compromised pulmonary reserve after prior surgical resection.<br /><br />Overall, the study highlights the efficacy and safety of image-guided thermal ablation as a treatment option for early-stage NSCLC. It provides valuable information for clinicians and policymakers in determining the appropriate treatment strategies for medically inoperable patients.

Asset Subtitle

Soheil Kooraki

Meta Tag

Speaker Soheil Kooraki

Topic Early-Stage NSCLC: New Technology & Innovations

Keywords

UCLA

study

medically inoperable patients

NSCLC

thermal ablation

survival rates

complications

recurrent disease

treatment option

early-stage NSCLC