2023 World Conference on Lung Cancer (Posters)-EP07.02. The Role of Online MR-guided Multi-Fraction Stereotactic Ablative Radiotherapy in Lung Tumors

EP07.02. The Role of Online MR-guided Multi-Fraction Stereotactic Ablative Radiotherapy in Lung Tumors - PDF(Abstract)

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This study evaluated the potential benefits and outcomes of online MR-guided multi-fraction stereotactic ablative radiotherapy (SAbR) in the treatment of peripheral lung tumors. The study included 45 patients with 60 lung tumors who underwent the treatment, which involved multiple fractions of radiation therapy guided by real-time MRI. The primary endpoints of the study were local control and overall survival. <br /><br />The results showed that the treatment achieved excellent local control rates, with 1- and 2-year local control rates of 97.7% and 87.6%, respectively. There were no grade 3 toxicities recorded, and no significant decline in pulmonary function parameters. The most common grade 2 treatment-related toxicities were radiation pneumonitis and cough. <br /><br />The study also found that the online adaptive MR-guided SAbR treatment resulted in improved dose coverage of target volumes. The plans were re-optimized in 91% of cases, with the largest changes observed in the coverage of the target volumes. There was a median increase of 5.2% in the coverage of PTV V100%, and increases in PTV/GTV D95% and D98% of 5.0% and 6.5%, respectively. There were also slight increases in PTV/GTV D50% and Dmean. <br /><br />Overall, the study concludes that online adaptive MR-guided SAbR is an effective and safe treatment option for early-stage non-small cell lung cancer and lung metastases. It achieves excellent local control rates with improved dose coverage of target volumes, without significant decline in pulmonary function. Future research may focus on further evaluating the long-term outcomes and toxicity profile of this treatment approach.

Asset Subtitle

Chukwuka Eze

Meta Tag

Speaker Chukwuka Eze

Topic Early-Stage NSCLC: New Technology & Innovations

Keywords

online MR-guided multi-fraction stereotactic ablative radiotherapy

peripheral lung tumors

real-time MRI

local control

overall survival

radiation pneumonitis

cough

dose coverage

target volumes

non-small cell lung cancer