2023 World Conference on Lung Cancer (Posters)-EP07.02. Utilization of Real-time MRI-guided Stereotactic Ablative Body Radiotherapy in NSCLC, One Step forward Precise Targeting in Radiotherapy

EP07.02. Utilization of Real-time MRI-guided Stereotactic Ablative Body Radiotherapy in NSCLC, One Step forward Precise Targeting in Radiotherapy - PDF(Abstract)

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This study focused on the utilization of real-time MRI-guided stereotactic ablative body radiotherapy (SABR) in the treatment of non-small cell lung cancer (NSCLC). SABR is an effective treatment for early-stage lung tumors, but tumor motion poses a challenge in delivering precise radiation. The use of a magnetic resonance imaging-guided linear accelerator (MR-Linac) allows for real-time tumor tracking, improving targeting accuracy. <br /><br />The study included 41 patients with NSCLC who underwent SABR using MR-Linac, and 40 patients who underwent SABR using computed tomography (CT)-based modalities for comparison. The SABR dose ranged from 48 to 60 Gy in 3-5 fractions. The primary endpoint was to assess if MR-Linac resulted in a lower radiation volume compared to CT-based SABR. <br /><br />The results showed no significant difference in the gross tumor volume between the MR and CT groups. However, the planning target volume was significantly smaller in the MR group. The 1-year local control rates for the MR and CT groups were 92.1% and 75.4% respectively, with no significant difference in overall survival rates. Most patients tolerated the treatment well, with no significant difference in radiation-related toxicities between the MR and CT groups. <br /><br />In conclusion, the use of MR-Linac in SABR for lung cancer reduces the volume of the irradiated field without compromising the local control rate. The study suggests that with further follow-up, recruitment of additional patients, and improvements in planning abilities, even better results can be expected in the future.

Asset Subtitle

Yoo Kang Kwak

Meta Tag

Speaker Yoo Kang Kwak

Topic Early-Stage NSCLC: New Technology & Innovations

Keywords

real-time MRI-guided SABR

non-small cell lung cancer

MR-Linac

tumor motion

radiation therapy

tumor tracking

CT-based SABR

radiation volume

local control rate

lung cancer treatment