2023 World Conference on Lung Cancer (Posters)-EP07.02. Utilization of Real-time MRI-guided Stereotactic Ablative Body Radiotherapy in NSCLC, One Step forward Precise Targeting in Radiotherapy

EP07.02. Utilization of Real-time MRI-guided Stereotactic Ablative Body Radiotherapy in NSCLC, One Step forward Precise Targeting in Radiotherapy - PDF(Slides)

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This study focused on the utilization of real-time MRI-guided stereotactic ablative body radiotherapy (SABR) for the treatment of non-small cell lung cancer (NSCLC). SABR is a non-invasive treatment that delivers high doses of radiation to a small-sized tumor mass within five sessions. It is recommended for inoperable patients with early-stage NSCLC due to its convenience and acceptable outcomes. However, there is a challenge in lung SABR due to the breathing-related movement of the tumor and adjacent organs.<br /><br />The study evaluated the advantages of using an MR-Linac, which combines magnetic resonance imaging (MRI) with linear accelerators, in comparison to conventional CT-based modalities in SABR for lung tumors. The MR-Linac allows for the exact observation of tumor movement during treatment and enables the beam to be turned on and off based on the tumor position.<br /><br />The study, conducted retrospectively at a single institution, compared the MR group (using MR-Linac) with the CT group (using CT-based modalities). The inclusion criteria included patients with NSCLC tumors less than 4.5 cm in diameter treated with SABR. The results showed no significant difference in tumor volume between the two groups, but the planning target volume (PTV) was significantly smaller in the MR group by almost 40%.<br /><br />There were no significant differences in the frequency of radiation-related toxicities between the MR and CT groups. The study concluded that MR-Linac in SABR for lung cancer can reduce the volume of the irradiated field without compromising local control rate. The researchers anticipate reporting better results in the future with further follow-up, recruitment of more patients, and improved planning abilities.

Asset Subtitle

Yoo Kang Kwak

Meta Tag

Speaker Yoo Kang Kwak

Topic Early-Stage NSCLC: New Technology & Innovations

Keywords

real-time MRI-guided stereotactic ablative body radiotherapy

non-small cell lung cancer

SABR

high doses of radiation

inoperable patients

early-stage NSCLC

MR-Linac

magnetic resonance imaging

linear accelerators

CT-based modalities