2023 World Conference on Lung Cancer (Posters)-EP07.04. ALK Rearrangement Is Associated with Early Lymphatic Spread in Resected LUAD with Negative Preoperative Mediastinal Staging

EP07.04. ALK Rearrangement Is Associated with Early Lymphatic Spread in Resected LUAD with Negative Preoperative Mediastinal Staging - PDF(Abstract)

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This study aimed to investigate the risk of unexpected nodal metastases in early stage non-small cell lung cancer (NSCLC) patients without evidence of nodal disease prior to surgery, based on the presence of the ALK rearrangement oncogene. A total of 573 patients who underwent radical treatment for early stage NSCLC without nodal disease were included in the study. The variables that showed a significant correlation with the upstaging rate at the multivariate analysis were grading, histological subtype, number of resected nodes, ALK rearrangement, and PD-L1 status. The analysis of the ALK rearrangements subgroup showed that 72.7% of patients with nodal upstaging had tumors less than 3 cm. ALK rearranged patients had a better, but not significant disease-free survival. The presence of ALK rearrangement was associated with a higher risk of unforeseen nodal metastases in patients with clinical node-negative early stage NSCLC. However, there were no statistically significant differences in survival according to the ALK status. This study highlights the importance of identifying predictive factors for nodal metastases in order to optimize treatment strategies for early stage NSCLC.

Asset Subtitle

Filippo Tommaso Gallina

Meta Tag

Speaker Filippo Tommaso Gallina

Topic Early-Stage NSCLC: Progress in Pathology

Keywords

nodal metastases

early stage

NSCLC

ALK rearrangement

upstaging rate

multivariate analysis

grading

histological subtype

PD-L1 status

treatment strategies