2023 World Conference on Lung Cancer (Posters)-EP07.04. Analysis of Radiologic-Pathologic Correlation for Subsolid Lung Adenocarcinoma Using the Whole-Mount Section Technique: A Prospective Study

EP07.04. Analysis of Radiologic-Pathologic Correlation for Subsolid Lung Adenocarcinoma Using the Whole-Mount Section Technique: A Prospective Study - PDF(Slides)

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The histologic features of ground glass opacities (GGO) and solid component regions in subsolid lung adenocarcinomas on thin-sectioned CT scans were investigated in a prospective clinical study. The study included patients with subsolid tumors who underwent segmentectomy or lobectomy. Pathologic whole-mount sections were made after the resection of the specimens and were digitized. Radiologic and pathologic cross sections of the tumors were matched, and the radiologic solid and GGO regions were delineated on the pathologic sections. The sizes of the radiologic tumors and solid components were compared to the sizes of the pathologic tumors and invasive parts. The prevalence and percentage of histologic subtypes of lung adenocarcinoma according to the 2015 WHO classification were evaluated.<br /><br />The results showed that the mean radiologic tumor size was larger than the mean pathologic tumor size, while the mean radiologic solid component size was smaller than the mean pathologic invasive part size. For pure GGO nodules, the prevalence of lepidic, acinar, and papillary subtypes was high, while micropapillary or solid subtypes did not exist. For part-solid tumors, there were various subtypes present in both the GGO and solid regions.<br /><br />The study included 102 patients with non-mucinous lung adenocarcinomas, and the mean age of the patients was 58.9 years. There were 20 pure GGO nodules and 82 part-solid nodules. The histologic analysis revealed cases of adenocarcinoma in situ, minimally invasive adenocarcinomas, and invasive adenocarcinomas.<br /><br />In conclusion, the radiologic tumor size was larger than the pathologic tumor size in subsolid lung adenocarcinomas, while the solid component size was smaller than the pathologic invasive component size. Different histologic subtypes were observed in pure GGO nodules and part-solid tumors, suggesting the importance of accurate characterization and classification of subsolid lung adenocarcinomas.

Asset Subtitle

Chaoqiang Deng

Meta Tag

Speaker Chaoqiang Deng

Topic Early-Stage NSCLC: Progress in Pathology

Keywords

ground glass opacities

subsolid lung adenocarcinomas

thin-sectioned CT scans

prospective clinical study

segmentectomy

lobectomy

pathologic whole-mount sections

radiologic solid component

histologic subtypes

2015 WHO classification