2023 World Conference on Lung Cancer (Posters)-EP07.04. Construction of Genome Atlas for lung Nodule and Molecular Insight into Lung Adenocarcinoma Development in Chinese Population

EP07.04. Construction of Genome Atlas for lung Nodule and Molecular Insight into Lung Adenocarcinoma Development in Chinese Population - PDF(Abstract)

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In this study, researchers aimed to understand why some lung nodules develop into malignancies while others remain benign. They compiled a genome atlas using 465 pulmonary nodule tissue samples from Chinese patients, including benign samples, atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and invasive adenocarcinoma (IA). The samples were analyzed using whole exome sequencing, transcriptome sequencing, and target DNA methylation sequencing.<br /><br />The researchers found that the emergence and mutation burden of EGFR and TP53 mutations were significant drivers for the development of early lung cancers. The frequency of EGFR mutations increased with disease progression, suggesting that these mutations were not an initiator but an accelerator in cancer formation. Transcriptome-based analysis revealed four subtypes of lung nodules with different molecular features and immune cell infiltrations. Estrogen/Androgen response was found to be associated with the EGFR pathway, which may inform a novel therapeutic strategy for lung cancer treatment.<br /><br />Stem cell pathways enriched in pre-invasive nodules, including Notch, Wnt/β-catenin, and hedgehog signaling, were implicated in preventing invasion and promoting NK cell infiltration as part of host immunosurveillance. Epigenetic regulation through various genes played a crucial role in lung cancer initiation and development.<br /><br />Overall, this study provides insights into the molecular mechanisms of neoplastic progression in lung adenocarcinoma and identifies potential therapeutic targets for lung cancer treatment. The multi-omics profiling used in this research contributes to a better understanding of the genetic and molecular factors involved in the development of lung cancer.

Asset Subtitle

Wenhua Liang

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Speaker Wenhua Liang

Topic Early-Stage NSCLC: Progress in Pathology

Keywords

lung nodules

malignancies

genome atlas

pulmonary nodule tissue samples

EGFR mutations

transcriptome-based analysis

molecular features

stem cell pathways

host immunosurveillance

therapeutic targets