2023 World Conference on Lung Cancer (Posters)-EP07.04. Early-Stage Low Malignant Potential Adenocarcinomas: A Histological Category With A Significantly Better Prognosis

EP07.04. Early-Stage Low Malignant Potential Adenocarcinomas: A Histological Category With A Significantly Better Prognosis - PDF(Abstract)

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This study examines a new subcategory of invasive adenocarcinoma called "low malignant potential adenocarcinoma" (LMPA) and its prognosis in patients with early-stage lung cancer. The researchers reviewed the clinical characteristics and pathological specimens of patients who underwent lung adenocarcinoma resection from 2005 to 2014. They excluded patients with certain tumor characteristics, size, and disease progression, resulting in 80 patients who met the criteria for LMPA.<br /><br />The pathological stage of LMPA ranged from IA1 to IA3, with a mean number of resected nodes of 8.4 and mediastinal resected nodes of 4.5. The mean follow-up period was 67-39 months. During the study period, all 19 patient deaths occurred in the non-LMPA group, while 33 patients experienced a recurrence, with 4 in the LMPA group and 29 in the non-LMPA group.<br /><br />Regarding overall survival (OS), LMPA patients had a 5-10 year OS of 100%, compared to 70.9% and 50.8% in non-LMPA patients. The study also found that a higher number of resected nodes (≥10) was associated with better survival. LMPA and a higher number of resected nodes were the only significant favorable prognostic factors.<br /><br />The study concludes that LMPA patients have an excellent prognosis, similar to adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA), suggesting that this category should be considered for specific follow-up schedules. These findings contribute to understanding the pathology and prognosis of early-stage lung cancer.

Asset Subtitle

Filippo Lococo

Meta Tag

Speaker Filippo Lococo

Topic Early-Stage NSCLC: Progress in Pathology

Keywords

invasive adenocarcinoma

low malignant potential adenocarcinoma

prognosis

early-stage lung cancer

clinical characteristics

pathological specimens

lung adenocarcinoma resection

LMPA

overall survival

resected nodes