2023 World Conference on Lung Cancer (Posters)-EP07.04. Factors Associated with Postoperative Recurrence in Early NSCLC with EGFR Mutation: Analysis of Korean National Population Data

EP07.04. Factors Associated with Postoperative Recurrence in Early NSCLC with EGFR Mutation: Analysis of Korean National Population Data - PDF(Slides)

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Pdf Summary

A study conducted in Korea aimed to identify risk factors for early postoperative relapse in patients with resectable non-small cell lung cancer (NSCLC), specifically those with the EGFR mutation. The study analyzed data from the Korean Association for Lung Cancer Registry, including 3,176 patients who underwent curative resection. Among the patients with the EGFR mutation, 5.1% experienced early recurrence within 1 year of surgery, while 14.0% experienced late recurrence. The study found that patients with higher T, N, and TNM stage, as well as those with pleural invasion, were more likely to experience early recurrence. Patients with parietal pleural invasion had worse recurrence-free survival compared to those with visceral pleural invasion or no pleural invasion. In multivariate analysis, age, pathologic N and TNM stage, pleural invasion, and surgery type were significantly associated with recurrence-free survival. Patients with the EGFR mutation and a large tumor burden or risk of incomplete resection may benefit from adjuvant EGFR tyrosine kinase inhibitors (TKIs) after surgery. Overall, these findings provide valuable insights into risk factors and potential treatment strategies for patients with resectable NSCLC, particularly those with the EGFR mutation.

Asset Subtitle

Jeong Uk Lim

Meta Tag

Speaker Jeong Uk Lim

Topic Early-Stage NSCLC: Progress in Pathology

Keywords

Korea

study

risk factors

early postoperative relapse

resectable NSCLC

EGFR mutation

curative resection

pleural invasion

recurrence-free survival

adjuvant TKIs