2023 World Conference on Lung Cancer (Posters)-EP07.04. Pleural CEA and SUVmax as Predictors of Visceral Pleural Invasion in Clinical T1N0M0 Lung Adenocarcinoma

EP07.04. Pleural CEA and SUVmax as Predictors of Visceral Pleural Invasion in Clinical T1N0M0 Lung Adenocarcinoma - PDF(Slides)

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In this study, the researchers aimed to determine if intraoperative pleural carcinoembryonic antigen (pCEA) levels and maximum standardized uptake value (SUVmax) can be used as predictive markers of visceral pleural invasion (VPI) in patients with clinical T1N0M0 lung adenocarcinoma. They retrospectively reviewed the medical records of 613 patients who underwent lung resection for non-small cell lung cancer (NSCLC), and included 390 patients with clinical stage I adenocarcinoma with a tumor size greater than 30 mm. The patients were divided into a pleural contact group and a non-pleural contact group based on computed tomography (CT) findings.<br /><br />The researchers used a receiver operating characteristic (ROC) curve analysis to assess the association between pCEA, SUVmax, and VPI. They found that pCEA levels of 2.565 ng/ml and SUVmax of 4.25 were highly predictive of VPI in patients with pleural contact. Logistic regression analysis showed that both pCEA and SUVmax were significant risk factors for VPI in the pleural contact group.<br /><br />The study suggests that in clinical stage I lung adenocarcinoma patients with pleural contact, pCEA and SUVmax can serve as predictive indicators of VPI. These markers may help in determining appropriate surgical plans for lung cancer patients.<br /><br />VPI is a poor prognostic factor that contributes to the upstaging of early lung cancers. However, preoperative assessment of VPI has limitations. This study provides insight into potential markers that can aid in the preoperative evaluation of VPI in lung adenocarcinoma patients. Further research is needed to validate these findings and determine the clinical utility of pCEA and SUVmax as predictive markers for VPI.

Asset Subtitle

GaYoung Yoo

Meta Tag

Speaker GaYoung Yoo

Topic Early-Stage NSCLC: Progress in Pathology

Keywords

pCEA levels

SUVmax

visceral pleural invasion

lung adenocarcinoma

non-small cell lung cancer

pleural contact

computed tomography

risk factors

surgical plans

preoperative evaluation