2023 World Conference on Lung Cancer (Posters)-EP07.04. Spread through Air Spaces in Non-small Cell Lung Cancer. Clinical and Pathological Associations

EP07.04. Spread through Air Spaces in Non-small Cell Lung Cancer. Clinical and Pathological Associations - PDF(Abstract)

Back to course

Pdf Summary

This study aimed to determine the incidence of tumor spread through air space (STAS) in non-small cell lung cancer (NSCLC) patients and its association with clinicopathological characteristics. A total of 192 NSCLC patients who underwent surgical resection at a single center between 2015 and 2021 were included in the study. The majority of patients were male (68.8%) with a median age of 68.0 years. The most common histology type was adenocarcinoma (63.0%), followed by squamous-cell carcinoma (21.4%) and other histologies (15.6%). The majority of patients had stage I disease (69.3%), followed by stage II (11.5%), stage III (13.5%), and stage IV (2.1%). STAS was observed in 34.4% of surgical specimens. <br /><br />The study found no significant association between STAS and age, sex, smoking status, histology type, stage, or maximum standardized uptake value on positron emission tomography. However, there was a significant association between STAS and lymphatic invasion and vascular invasion. Patients with STAS were more likely to have lymphatic invasion (58.1% vs. 29.6%) and vascular invasion (54.0% vs. 31.1%) compared to those without STAS. <br /><br />The findings of this study are consistent with previous reports worldwide, highlighting the association between STAS and lympho-vascular invasion. However, further studies with larger sample sizes are needed to validate these findings. STAS has been recognized as a novel histologic pattern of invasion associated with poor prognosis in NSCLC. Understanding the clinicopathological characteristics associated with STAS can help guide treatment decisions and improve patient outcomes.

Asset Subtitle

Virginia Calvo de Juan

Meta Tag

Speaker Virginia Calvo de Juan

Topic Early-Stage NSCLC: Progress in Pathology

Keywords

tumor spread through air space

non-small cell lung cancer

incidence

clinicopathological characteristics

surgical resection

histology type

stage

lymphatic invasion

vascular invasion

prognosis