2023 World Conference on Lung Cancer (Posters)-EP07.04. Spread through Air Spaces in Non-small Cell Lung Cancer. Clinical and Pathological Associations

EP07.04. Spread through Air Spaces in Non-small Cell Lung Cancer. Clinical and Pathological Associations - PDF(Slides)

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This study aimed to investigate the incidence of tumor spread through air space (STAS) in non-small cell lung cancer (NSCLC) patients and its association with clinicopathological characteristics. The researchers retrospectively analyzed data from 192 NSCLC patients who underwent surgical resection at a single center from 2015 to 2021. The majority of the patients were male (68.8%) with a median age of 68.0 years. Adenocarcinoma was the most common histology type (63.0%), followed by squamous-cell carcinoma (21.4%) and other histologies (15.6%). The majority of patients had stage I disease (69.3%), followed by stage II (11.5%), stage III (13.5%), and stage IV (2.1%).<br /><br />STAS was observed in 34.4% of the surgical specimens. The researchers found no statistically significant association between STAS and age, sex, smoking status, histology type, stage, or maximum standardized uptake value (SUVmax). However, there was a statistically significant association between STAS and the presence of lymphatic invasion (p = 0.001) and vascular invasion (p = 0.003). The study suggests that STAS may be associated with a higher risk of lymphatic and vascular invasion in NSCLC patients.<br /><br />These findings are consistent with other reports from around the world. However, further studies with larger sample sizes are needed to validate these results. Understanding the association between STAS and clinicopathological characteristics can help improve the prognostic evaluation and treatment strategies for NSCLC patients.

Asset Subtitle

Virginia Calvo de Juan

Meta Tag

Speaker Virginia Calvo de Juan

Topic Early-Stage NSCLC: Progress in Pathology

Keywords

tumor spread through air space

STAS

non-small cell lung cancer

NSCLC

incidence

clinicopathological characteristics

adenocarcinoma

squamous-cell carcinoma

lymphatic invasion

vascular invasion