2023 World Conference on Lung Cancer (Posters)-EP07.05. Prognostic Factors in Non-Small-Cell Lung Cancer Treated with Chemoimmunotherapy or Chemotherapy: A Real-World Data Study

EP07.05. Prognostic Factors in Non-Small-Cell Lung Cancer Treated with Chemoimmunotherapy or Chemotherapy: A Real-World Data Study - PDF(Slides)

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This study aimed to determine which patient characteristics with non-small cell lung cancer (NSCLC) stages I-III would best benefit from treatment with chemotherapy (CT) or chemoimmunotherapy (Chemo-IO). The study analyzed real-world data from the AACR Project GENIE BPC NSCLC v2.0 dataset, including 536 patients diagnosed with stage I-III NSCLC who received either CT or Chemo-IO regimens. The prognostic factors evaluated were age, sex, stage, and histopathology subtype. <br /><br />The results showed that there were no significant differences in overall survival (OS) between the CT and Chemo-IO groups for all patients. However, there were some significant differences in OS based on certain prognostic factors. For age, there was no significant difference in OS between patients aged 65 and older and those younger than 65. Sex had a significant effect on OS, with females having higher OS than males in both the CT and Chemo-IO groups. Histology subtype also had a significant effect on OS, with adenocarcinoma patients having higher OS than squamous cell carcinoma (SCC) and other subtypes in both the CT and Chemo-IO groups. Tumor stage also influenced OS, with stage I-II patients having higher OS than stage III patients in both the CT and Chemo-IO groups.<br /><br />In conclusion, this study found that the OS benefit from CT or Chemo-IO is influenced by the patient's sex, histology subtype, and tumor stage, while age had no significant effect. The findings suggest that personalized treatment strategies should be considered in clinical practice and future guidelines for NSCLC patients. The study also acknowledges the effort of individuals involved in the research.

Asset Subtitle

Ayah Bani Mostafa

Meta Tag

Speaker Ayah Bani Mostafa

Topic Early-Stage NSCLC: Pushing the Boundaries

Keywords

non-small cell lung cancer

NSCLC

chemotherapy

chemoimmunotherapy

prognostic factors

overall survival

age

sex

histopathology subtype

tumor stage