2023 World Conference on Lung Cancer (Posters)-EP08.02. A Prospective Study of Gallium-68 Ventilation and Perfusion PET/CT Before, During, and After Radiotherapy in Patients with NSCLC

EP08.02. A Prospective Study of Gallium-68 Ventilation and Perfusion PET/CT Before, During, and After Radiotherapy in Patients with NSCLC - PDF(Slides)

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This study aimed to evaluate the use of Gallium V/Q PET/CT in assessing and predicting clinical outcomes in patients with non-small cell lung cancer (NSCLC) undergoing (chemo)radiotherapy. The researchers investigated how ventilation and perfusion in the lung changed over time, and how these changes related to clinical outcomes. They also examined whether conventional radiotherapy dose constraints, applied to functional lung, could predict for clinical toxicity.<br /><br />The study included patients undergoing radical (chemo)radiotherapy for NSCLC. V/Q PET/CT scans were performed before radiotherapy, mid-treatment, and at 4 weeks, 3 months, and 12 months post-radiotherapy. Clinical reviews and pulmonary function tests (PFTs) were conducted at the same time points.<br /><br />The results showed a reduction in both ventilation and perfusion over time after radiotherapy, as evidenced by serial images for individual patients. There was also a small drop in the proportion of both ventilated and perfused lung from baseline to 12 months post-radiotherapy. However, there was no significant relationship between changes in ventilation and perfusion and the incidence of pneumonitis.<br /><br />A reduction in the proportion of both ventilated and perfused lung was associated with a decrease in forced expiratory volume in 1 second (FEV1). However, there was no association between lung ventilation or perfusion and clinical toxicity.<br /><br />Toxicity was assessed based on the radiation dose received by anatomical, ventilated, and perfused lung. However, there were no significant associations observed between the mean lung dose or lung volume receiving at least 20 Gy and the occurrence of pneumonitis.<br /><br />In conclusion, radiotherapy led to a decrease in lung ventilation and perfusion, which was associated with a mild reduction in FEV1. However, there was no association between lung ventilation or perfusion and clinical toxicity. Additionally, the study found that radiotherapy dose limits, applied to functional lung, did not predict clinical outcomes.

Asset Subtitle

Neil Wallace

Meta Tag

Speaker Neil Wallace

Topic Local-Regional NSCLC: Multimodality Therapy

Keywords

Gallium V/Q PET/CT

non-small cell lung cancer

NSCLC

(chemo)radiotherapy

ventilation

perfusion

clinical outcomes

pneumonitis

forced expiratory volume in 1 second

lung dose