2023 World Conference on Lung Cancer (Posters)-EP08.02. Correlation of Quantified Metabolic Activity with Gross Tumor Volume in Patients with Non Small Cell Lung Cancer

EP08.02. Correlation of Quantified Metabolic Activity with Gross Tumor Volume in Patients with Non Small Cell Lung Cancer - PDF(Slides)

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This study aimed to evaluate the correlation between the maximum standardized uptake value (SUVmax) and the gross tumor volume (GTV) in patients with non-small cell lung cancer (NSCLC) in terms of survival prognosis. The study included 58 patients with locally advanced or medically inoperable NSCLC who underwent three-dimensional conformal radiotherapy between 2012 and 2016. PET/CT examinations were used for staging and radiotherapy planning. The patients were divided into four groups based on their GTV and SUVmax values. The primary endpoints were disease-free survival (DFS) and overall survival (OS). <br /><br />The results showed that there was a significant correlation between the groups with large GTV and survival, particularly in the group with large GTV and high SUVmax. However, the difference in survival prognosis was more significant in the groups with small GTV, favoring the group with small GTV and low SUVmax values. The power of GTV and SUVmax individually to predict survival was not significantly different. The two-year DFS and OS rates varied among the different groups, with the group with small GTV and low SUVmax having the best survival outcomes. <br /><br />In conclusion, this study found that GTV was related to SUVmax values in predicting the prognosis of patients with NSCLC, except in the group with small GTV and high SUVmax where the survival outcomes were the worst. SUVmax was found to have a stronger prognostic value in this group. However, the individual power of GTV and SUVmax as prognostic factors was not demonstrated in the majority of patients, only their combination.

Asset Subtitle

Danijela Scepanovic

Meta Tag

Speaker Danijela Scepanovic

Topic Local-Regional NSCLC: Multimodality Therapy

Keywords

correlation

maximum standardized uptake value

SUVmax

gross tumor volume

GTV

non-small cell lung cancer

NSCLC

survival prognosis

disease-free survival

overall survival