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2023 World Conference on Lung Cancer (Posters)
EP08.02. Dosimetric Comparison of Free- Breathing ...
EP08.02. Dosimetric Comparison of Free- Breathing versus Respiratory Motion-managed Radiotherapy with 4D-CT Based VMAT in Lung Cancer - PDF(Slides)
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Pdf Summary
A study was conducted to compare the dosimetric factors of free-breathing volumetric arc therapy (VMAT) plans with respiratory motion-managed VMAT plans using 4D-CT in patients with non-small cell lung cancer (NSCLC). The aim was to reduce side effects and improve treatment outcomes. The study included 31 patients who were treated between January 2019 and January 2022. The median age of the patients was 63 years, and the majority were in stage III of the disease. The results showed that the tumor volumes were similar in both types of plans, but the planning target volumes (PTV) were significantly lower in the respiratory motion-managed VMAT plans. The dose covering 95% of the tumor and PTV volumes was significantly higher in the motion-managed plans, while doses to organs at risk (OAR) were significantly lower. Grade 1-2 radiation pneumonitis was observed in 35% of the evaluated cases, but there were no grade 3 or higher side effects. The study also found that the number of treatment fractions, lung V30, and ITV volume were significant factors for overall survival. The median overall survival was 17.8 months, with a 2-year overall survival rate of 26%. The study concluded that respiratory motion-managed VMAT with 4D-CT provides accurate target coverage and reduces dose to OAR, suggesting its routine use in curative radiation therapy for lung cancer patients.
Asset Subtitle
Sureyya Sarihan
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Speaker
Sureyya Sarihan
Topic
Local-Regional NSCLC: Multimodality Therapy
Keywords
dosimetric factors
VMAT plans
respiratory motion-managed
4D-CT
non-small cell lung cancer
planning target volumes
organ at risk
radiation pneumonitis
overall survival
curative radiation therapy
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