2023 World Conference on Lung Cancer (Posters)-EP08.02. Dosimetric Contribution of LAD Artery Sparing RT Plan in Lung Cancer Patients Who Received Definitive RT

EP08.02. Dosimetric Contribution of LAD Artery Sparing RT Plan in Lung Cancer Patients Who Received Definitive RT - PDF(Slides)

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This study aimed to evaluate the dosimetric results of optimizing left anterior descending artery (LAD) in the radiotherapy (RT) treatment of lung cancer patients. The LAD artery sparing RT plan has been associated with a lower risk of major cardiac events. Thirty-seven patients who previously received RT for non-small cell lung cancer (NSCLC) without LAD optimization were selected for replanning. The LAD volume was constrained to less than 10% (LAD-V1510%) in the new plans without compromising target coverage or other organ-at-risk (OAR) dose-limiting parameters. <br /><br />The majority of patients were male (89%), with a mean age of 66 years. The previous plans were mainly performed with intensity-modulated radiotherapy (IMRT), while the new plans mostly used IMRT as well. The mean radiation therapy (RT) dose was 60Gy, and the fraction number was 30. The mean LAD-V15 in the previous plans was 49%, which was significantly reduced to 11% in the new plans (p<0.01). <br /><br />In 57% of the patients, the LAD-V15 was successfully reduced below 10% with replanning. In patients whose LAD-V15 could not be reduced below 10%, it was significantly decreased from 49% to 18%. The doses to the heart and LAD were also significantly reduced in the new plans compared to the previous plans (p<0.01). <br /><br />Overall, the results of this study indicate that LAD optimization can effectively reduce LAD dose exposure while maintaining optimal target coverage and doses to other OARs in lung cancer patients receiving RT. This approach may help lower the risk of major cardiac events in these patients.

Asset Subtitle

Serap Akyürek

Meta Tag

Speaker Serap Akyürek

Topic Local-Regional NSCLC: Multimodality Therapy

Keywords

dosimetric results

left anterior descending artery

radiotherapy treatment

lung cancer patients

LAD artery sparing

major cardiac events

non-small cell lung cancer

replanning

intensity-modulated radiotherapy

LAD dose exposure