2023 World Conference on Lung Cancer (Posters)-EP08.02. Higher Radiation Dose to Immune Cells is a Negative Prognostic Factor in Locally Advanced Non-Small Cell Lung Cancer (LA-NSCLC)

EP08.02. Higher Radiation Dose to Immune Cells is a Negative Prognostic Factor in Locally Advanced Non-Small Cell Lung Cancer (LA-NSCLC) - PDF(Abstract)

Back to course

Pdf Summary

A study presented at the WCLC 2023 conference revealed that higher radiation doses to immune cells is a negative prognostic factor in locally advanced non-small cell lung cancer (LA-NSCLC) patients. The researchers hypothesized that effective radiation dose to immune cells (EDIC) would impact patient outcomes and that proton radiotherapy would result in lower EDIC.<br /><br />The study included 786 LA-NSCLC patients who underwent chemoradiotherapy (CRT) with or without consolidative immunotherapy. The patients were divided into high and low EDIC groups based on median EDIC value. The results showed that patients with high EDIC had larger tumors, higher overall stage, and more squamous histology. They also experienced worse progression-free survival (PFS), locoregional failure (LRF), time to distant metastasis (TTDM), and overall survival (OS). Additionally, patients with high EDIC had a higher incidence of unplanned hospitalizations within 90 days.<br /><br />Among patients who received consolidative immunotherapy, those with high EDIC had worse PFS and OS. Multivariable modeling confirmed that high EDIC was associated with worse OS, along with higher ECOG, squamous histology, and gross tumor volume (GTV). Proton radiotherapy was identified as a predictor of low EDIC.<br /><br />The study concluded that high EDIC is a negative prognostic factor for LA-NSCLC patients treated with CRT with or without immunotherapy. The use of proton radiotherapy was associated with lower EDIC, suggesting that strategies to limit EDIC should be considered during radiotherapy planning for LA-NSCLC.

Asset Subtitle

Nikhil Yegya-Raman

Meta Tag

Speaker Nikhil Yegya-Raman

Topic Local-Regional NSCLC: Multimodality Therapy

Keywords

radiation doses

immune cells

prognostic factor

LA-NSCLC

chemoradiotherapy

progression-free survival

overall survival

unplanned hospitalizations

proton radiotherapy

radiotherapy planning