2023 World Conference on Lung Cancer (Posters)-EP08.02. Is Moderate-intensity Stereotactic Body Radiation Therapy for Ultra-central Lung Tumor a Feasible Option?

EP08.02. Is Moderate-intensity Stereotactic Body Radiation Therapy for Ultra-central Lung Tumor a Feasible Option? - PDF(Abstract)

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In this study, the authors investigated the feasibility and effectiveness of moderate-intensity stereotactic body radiation therapy (SBRT) for ultra-central (UC) lung tumors. UC tumors are located near the bronchial trees and pose a challenge in treatment due to the risk of serious complications such as hemoptysis. The researchers performed moderate-intensity SBRT with a dose of 45 to 60 Gy in 10 fractions, ensuring that the maximum dose in the target volume did not exceed 110% of the prescribed dose. <br /><br />The primary outcomes of the study were tumor response and overall survival. Out of the 21 patients who underwent SBRT, one patient was excluded from the study as they received a second SBRT course at another institution and died from hemoptysis. The remaining 20 patients were included in the study, with a median follow-up time of 15.8 months. <br /><br />The results showed that 10 patients (50%) achieved a complete response, 5 (25%) had a partial response, 2 (10%) had stable disease, and 3 (15%) had progressive disease. This resulted in an overall response rate of 75% and a disease control rate of 90%. Patients with progressive disease experienced local progression around 8.3 months after SBRT. <br /><br />The one-year and two-year overall survival rates were 79.1% and 63.9%, respectively. Five patients died from causes unrelated to radiation therapy. Only two patients experienced mild toxicities, with one reporting grade 2 esophageal pain and another with grade 1 cough. No grade 3 or higher toxicities were reported. <br /><br />Based on these findings, the authors concluded that moderate-intensity SBRT could be a feasible and effective treatment option for UC lung tumors. This approach may provide a curative chance for inoperable patients without the need for pneumonectomy.

Asset Subtitle

Chai Hong Rim

Meta Tag

Speaker Chai Hong Rim

Topic Local-Regional NSCLC: Multimodality Therapy

Keywords

moderate-intensity SBRT

stereotactic body radiation therapy

UC lung tumors

bronchial trees

hemoptysis

tumor response

overall survival

disease control rate

toxicities

curative chance