2023 World Conference on Lung Cancer (Posters)-EP08.02. Is Moderate-intensity Stereotactic Body Radiation Therapy for Ultra-central Lung Tumor a Feasible Option?

EP08.02. Is Moderate-intensity Stereotactic Body Radiation Therapy for Ultra-central Lung Tumor a Feasible Option? - PDF(Slides)

Back to course

Pdf Summary

This study examines the feasibility of using moderate-intensity stereotactic body radiation therapy (SBRT) for ultra-central (UC) lung tumors. SBRT is a non-invasive treatment method that delivers high-dose radiation to tumors in a short amount of time. UC tumors are those that are located adjacent to the proximal bronchial trees. While SBRT for UC tumors has the potential for serious side effects such as hemoptysis, it also offers a chance for curative treatment without the need for pneumonectomy.<br /><br />The study included 20 patients with UC tumors who underwent moderate-intensity SBRT. The median follow-up time was 15.8 months. Overall, 50% of patients achieved a complete response, 25% had a partial response, 10% had stable disease, and 15% showed disease progression. The one-year and two-year overall survival rates were 79.1% and 63.9% respectively, while the one-year and two-year local control rates were 87.1% and 76.2%.<br /><br />The paper provides two case examples to illustrate the effectiveness of SBRT for UC tumors. One patient with a large tumor obstructing the bronchus achieved a complete response after SBRT and remained disease-free at 17.7 months post-treatment. Another patient with metastatic lung cancer to the brain and chest also achieved a complete response after SBRT.<br /><br />One patient in the study died from treatment-related hemoptysis, although it is unclear if this was directly caused by SBRT. No other grade 3 or higher complications were reported.<br /><br />In conclusion, this study suggests that moderate-intensity SBRT could be a feasible and effective treatment option for UC tumors, providing curative and salvage opportunities without the need for pneumonectomy. Efforts to reduce hemoptysis, such as careful treatment planning and consideration of hemoptysis-related medications, are necessary. SBRT for UC tumors could be a viable, potentially curative option with efforts to minimize side effects.

Asset Subtitle

Chai Hong Rim

Meta Tag

Speaker Chai Hong Rim

Topic Local-Regional NSCLC: Multimodality Therapy

Keywords

SBRT

stereotactic body radiation therapy

UC lung tumors

moderate-intensity

non-invasive treatment

curative treatment

pneumonectomy

hemoptysis

overall survival rates

local control rates