2023 World Conference on Lung Cancer (Posters)-EP08.02. Parameters of FDG PET/CT Predicting Pathological Response to Neoadjuvant Immunotherapy in Stage II/III Non-small Cell Lung Cancer Patients

EP08.02. Parameters of FDG PET/CT Predicting Pathological Response to Neoadjuvant Immunotherapy in Stage II/III Non-small Cell Lung Cancer Patients - PDF(Abstract)

Back to course

Pdf Summary

This study aimed to determine if PET parameters could predict the pathological response to neoadjuvant immunotherapy in patients with stage II/III non-small cell lung cancer (NSCLC). The study included PET/CT images of NSCLC patients who underwent neoadjuvant therapy with pembrolizumab or nivolumab. PET parameters such as maxSUV, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were evaluated. The tumor to liver ratio (TLR) was also calculated. Changes in PET parameters before and after immunotherapy were analyzed. Clinical data and pathological results were collected.<br /><br />The results showed that higher maxSUVs of the primary tumor and total tumor were significantly associated with a pathological complete response (pCR) after immunotherapy. Additionally, higher TLG(2.5) and MTV(2.5) of total tumors were also associated with pCR. However, no significant associations were found with MTV(41%) or TLG(41%). Pre-IT TLR was higher in the pCR group, while post-IT TLR tended to be lower. Changes in maxSUV, TLG(2.5), MTV(2.5), and TLR of total tumors tended to be higher in the pCR group. MeanSUVs of the liver and spleen were also significantly higher in the pCR group.<br /><br />Overall, the study suggests that FDG PET/CT may be a useful indicator for predicting a pathological complete response in patients with stage II/III NSCLC who undergo neoadjuvant immunotherapy. Higher maxSUVs, TLG(2.5), MTV(2.5), and TLR before treatment were associated with a better response to immunotherapy. These findings may help guide treatment decisions and improve outcomes for NSCLC patients receiving neoadjuvant immunotherapy.

Asset Subtitle

Eun Seong Lee

Meta Tag

Speaker Eun Seong Lee

Topic Local-Regional NSCLC: Multimodality Therapy

Keywords

PET parameters

neoadjuvant immunotherapy

non-small cell lung cancer

NSCLC

pembrolizumab

nivolumab

maxSUV

metabolic tumor volume

total lesion glycolysis

tumor to liver ratio