2023 World Conference on Lung Cancer (Posters)-EP08.02. Prognostic Impacts of Lymphovascular Invasion of Resected Lung Adenocarcinoma after Induction Chemoradiotherapy

EP08.02. Prognostic Impacts of Lymphovascular Invasion of Resected Lung Adenocarcinoma after Induction Chemoradiotherapy - PDF(Abstract)

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This study aimed to investigate the prognostic factors of lung adenocarcinoma after induction chemoradiotherapy, specifically focusing on lymphovascular invasion (LVI) and histological subtypes. The researchers retrospectively reviewed patients with completely resected lung adenocarcinoma after induction chemoradiotherapy at their institution. LVI was defined as the presence of lymphatic or vascular invasion, and high-grade histological patterns were also analyzed. The effects of these pathological findings on recurrence-free survival (RFS) and overall survival (OS) were evaluated.<br /><br />The study included 56 patients, mostly male, with a median age of 64 years. The median observation time was 1743.5 days. Pathological complete response was observed in 6 patients, and 23.2% received adjuvant chemotherapy. The 5-year RFS and OS rates were 39.8% and 64.0%, respectively. LVI was present in 25.0% of patients and was significantly associated with worse RFS and OS. Specifically, lymphatic and vascular invasion were individually significant predictors of RFS in univariate analysis, with vascular invasion also being significant in multivariate analysis. Vascular invasion was a significant predictor of OS in both univariate and multivariate analysis. However, high-grade histological subtypes (micropapillary/solid patterns) did not impact RFS or OS.<br /><br />Based on these findings, the researchers concluded that LVI, especially vascular invasion, is a significant poor prognostic factor for recurrence and survival in lung adenocarcinoma after induction chemoradiotherapy. It serves as an important surrogate marker for the effectiveness of multimodal treatment. However, high-grade histological subtypes may not be reliable prognostic markers. The presence of LVI should be considered when deciding on additional postoperative therapy.

Asset Subtitle

Takafumi Kabuto

Meta Tag

Speaker Takafumi Kabuto

Topic Local-Regional NSCLC: Multimodality Therapy

Keywords

prognostic factors

lung adenocarcinoma

induction chemoradiotherapy

lymphovascular invasion

histological subtypes

recurrence-free survival

overall survival

pathological findings

adjuvant chemotherapy

multimodal treatment