2023 World Conference on Lung Cancer (Posters)-EP08.02. Prognostic Role of Baseline PET/CT Parameters in Frail Patients with Inoperable Node-Positive Stage IIB-IIIC/Recurrent NSCLC

EP08.02. Prognostic Role of Baseline PET/CT Parameters in Frail Patients with Inoperable Node-Positive Stage IIB-IIIC/Recurrent NSCLC - PDF(Slides)

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A study was conducted to determine the prognostic value of baseline PET/CT parameters in frail patients with inoperable node-positive stage IIB-IIIC/recurrent non-small cell lung cancer (NSCLC) who were undergoing moderately hypofractionated radiotherapy. The study analyzed 42 patients with poor prognostic factors and compromised pulmonary function. The patients received hypofractionated image-guided radiotherapy, and their PET/CT scans were analyzed to determine the prognostic markers for progression-free survival (PFS) and overall survival (OS). The PET parameters evaluated were metabolic tumor volume (MTV), standardized uptake value (SUV), and total lesion glycolysis (TLG) of the primary tumor and lymph node metastases.<br /><br />The results showed that patients with a higher MTV, SUVmax, and TLG had poorer outcomes in terms of PFS and OS. Specifically, a higher MTV (>36.6 cc) was associated with lower PFS and OS, while a higher SUVmax (>12.04) was associated with worse PFS. Additionally, a higher TLG was associated with inferior PFS. On multivariate analysis, only MTV remained a significant prognosticator of OS. <br /><br />The findings suggest that baseline PET parameters can serve as prognosticators for PFS and OS in frail patients with inoperable NSCLC undergoing moderately hypofractionated radiotherapy. This information can be useful in stratifying patients and potentially influencing future treatment algorithms. The study highlights the importance of considering PET parameters in treatment planning and suggests that further research is needed to investigate the role of radiotherapy alone or in combination with immunotherapy in similar patient cohorts.

Asset Subtitle

Chukwuka Eze

Meta Tag

Speaker Chukwuka Eze

Topic Local-Regional NSCLC: Multimodality Therapy

Keywords

baseline PET/CT parameters

frail patients

inoperable NSCLC

moderately hypofractionated radiotherapy

metabolic tumor volume

standardized uptake value

total lesion glycolysis

progression-free survival

overall survival

treatment planning