2023 World Conference on Lung Cancer (Posters)-EP08.03. Role of DCE MRI in Predicting Treatment Response to Induction Immunochemotherapy in Locally Advanced NSCLC Patients

EP08.03. Role of DCE MRI in Predicting Treatment Response to Induction Immunochemotherapy in Locally Advanced NSCLC Patients - PDF(Slides)

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This study aimed to investigate the predictive value of dynamic contrast enhanced (DCE) and diffusion-weighted (DW) magnetic resonance imaging (MRI) parameters for tumor response to induction immuno-chemotherapy in locally advanced non-small cell lung cancer (LA-NSCLC) patients. A total of 111 patients were analyzed in the study, and they were treated with induction immuno-chemotherapy. The DCE and DW-MRI data were acquired before and after the treatment. The parameters including Ktrans, Kep, Ve, Vp from DCE-MRI data and ADC from DW-MRI data were calculated. <br /><br />The pre-treatment Ktrans of primary tumor yielded the best area under the curve (AUC) value, indicating it had the best predictive value for tumor response. The pre-treatment Ve, post-treatment ADC, and Ktrans also had moderate AUC values. Patients were categorized into high Ktrans and low Ktrans groups, and the LA-NSCLC patients in the high Ktrans group had a better treatment response to induction immuno-chemotherapy than the patients in the low Ktrans group. <br /><br />Immunohistochemistry staining was performed to compare the infiltrations of immune cells in the high and low Ktrans groups. The high Ktrans group had higher infiltrations of CD3T cells, CD8T cells, CD68macrophages, and CD86macrphages than the low Ktrans group. However, there was no significant difference in CD163macrophages, CD206macrophages, and Ki67 between the two groups. <br /><br />In conclusion, the pre-treatment Ktrans of the primary lung tumor was a significant predictive factor for the response to induction immuno-chemotherapy in LA-NSCLC patients. A higher Ktrans value was correlated with a better treatment response and higher levels of CD3/CD8 T cell and CD68/CD86 macrophage infiltrations. This study suggests that DCE-MRI parameters can be useful in predicting treatment response and guiding therapy in LA-NSCLC patients.

Asset Subtitle

DaQuan Wang

Meta Tag

Speaker DaQuan Wang

Topic Local-Regional NSCLC: Novel Therapies & Trials

Keywords

dynamic contrast enhanced

diffusion-weighted

magnetic resonance imaging

tumor response

induction immuno-chemotherapy

locally advanced non-small cell lung cancer

Ktrans

ADC

immune cells

therapy