2023 World Conference on Lung Cancer (Posters)-EP08.04. Development of a Risk Score to Predict Postoperative Complications in Patients with Non-small Cell Lung Cancer

EP08.04. Development of a Risk Score to Predict Postoperative Complications in Patients with Non-small Cell Lung Cancer - PDF(Abstract)

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This study aimed to identify risk factors associated with postoperative complications in patients with non-small cell lung cancer (NSCLC). A retrospective analysis was conducted on 300 patients with NSCLC, and therapy-related complications were recorded. The primary endpoint was major complications, and the secondary endpoint was postoperative in-hospital mortality. A logistic regression model was developed to predict major complications.<br /><br />The results showed that 28% of patients developed major postoperative complications, including 5% with in-hospital mortality. The diffusion capacity of the lung to carbon monoxide (DLCO) was identified as a strong risk factor for major complications. Patients with major complications had significantly lower DLCO compared to those with no or minor complications. The final logistic regression model, adjusted for age and sex, identified three parameters that predicted major complications: DLCO, open surgery (compared to minimally invasive surgery), and duration of surgery. The model had an accuracy of 73% in predicting major complications.<br /><br />The study concluded that a high DLCO, short duration of surgery, and minimally invasive approach were associated with a lower risk of major postoperative complications. The model's accuracy in predicting major complications was reasonable at 73%. The study suggested that including more specific complication grades may enhance the predictive power of the regression model.<br /><br />In summary, this study developed a risk score to predict postoperative complications in patients with non-small cell lung cancer. DLCO, duration of surgery, and method of surgery were identified as significant risk factors for major complications. Implementing these risk factors into clinical practice may improve the prediction and management of postoperative complications in NSCLC patients.

Asset Subtitle

Makhmudbek Mallaev

Meta Tag

Speaker Makhmudbek Mallaev

Topic Local-Regional NSCLC: Toxicities of Multimodality Therapy

Keywords

non-small cell lung cancer

postoperative complications

retrospective analysis

major complications

in-hospital mortality

DLCO

open surgery

minimally invasive surgery

duration of surgery

accuracy