2023 World Conference on Lung Cancer (Posters)-EP09.01. Feasibility and Survival Outcomes of “Salvage Surgery” for Initially Clinical Stage IV Non-small Cell Lung Cancer

EP09.01. Feasibility and Survival Outcomes of “Salvage Surgery” for Initially Clinical Stage IV Non-small Cell Lung Cancer - PDF(Slides)

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This study evaluated the feasibility and survival outcomes of salvage surgery for initially clinical stage IV non-small cell lung cancer (NSCLC) following systemic therapy. Salvage surgery refers to lung resection for locally residual or relapsed disease after treatment. Traditionally, salvage surgery has been indicated for locally-advanced (stage III) NSCLC after chemoradiotherapy. However, due to advancements in systemic therapy, some patients with stage IV NSCLC experience a good response to systemic therapy and become candidates for salvage surgery. The study included 14 patients who had initially clinical stage IVA-B NSCLC and underwent salvage lung resection following systemic therapy. The patients' baseline characteristics, timing and indication for surgery, mode of resection, postoperative outcomes, and postoperative therapy were analyzed.<br /><br />The study found that salvage surgery for initially clinical stage IV NSCLC is feasible and selected patients obtained long-term overall survival. The 3-year overall survival rate was 74%, and there were no 90-day mortalities. However, the study also showed a short median recurrence-free survival of 1.7 years, indicating that clearance of metastatic lesions prior to surgery may not have been adequate. The impact of salvage surgery on survival was limited.<br /><br />Overall, the study highlights the potential benefits of salvage surgery for some patients with initially clinical stage IV NSCLC. However, further research is needed to determine the optimal candidates and timing for salvage surgery for this patient population.

Asset Subtitle

Tomoyuki Hishida

Meta Tag

Speaker Tomoyuki Hishida

Topic Metastatic NSCLC: Local Therapies - Effects

Keywords

salvage surgery

stage IV non-small cell lung cancer

systemic therapy

feasibility

survival outcomes

locally residual

relapsed disease

chemoradiotherapy

baseline characteristics

postoperative outcomes