2023 World Conference on Lung Cancer (Posters)-EP09.01. Outcomes of Surgical Treatment for Stage IV Non-Small Cell Lung Cancer (NSCLC) in a Population-Based Cohort

EP09.01. Outcomes of Surgical Treatment for Stage IV Non-Small Cell Lung Cancer (NSCLC) in a Population-Based Cohort - PDF(Abstract)

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This study examined the outcomes of surgical treatment for stage IV non-small cell lung cancer (NSCLC) in a population-based cohort. The researchers evaluated patients in a prospective cohort to identify the characteristics and outcomes of surgical resections for metastatic NSCLC. They compared the survival of patients with clinical stage IV disease to those with stage I-III NSCLC who underwent resections. The study also stratified the stage IV cohort based on the subsets of metastatic disease and analyzed the survival rates according to the site of metastasis.<br /><br />The results showed that patients with stage IV disease had a lower 5-year survival rate (45%) and median survival of 4 years compared to patients with stage I-III disease (61% and median survival of 8.3 years). The survival rates varied among the different subsets of metastatic disease, with soft tissue metastasis having the highest 5-year survival rate (67%) and hepatic metastasis having the lowest (29%).<br /><br />The study concluded that in a highly selected group of patients, curative-intent surgical resection was associated with better survival outcomes than expected for metastatic NSCLC. This highlights the potential benefit of carefully identifying patients with oligo-metastatic disease who may be candidates for aggressive surgical treatment. The researchers suggested that prospective studies are needed to standardize the selection criteria for these patients and determine the optimal treatment approach.<br /><br />In summary, this study provides valuable insights into the outcomes of surgical treatment for stage IV NSCLC. It emphasizes the importance of identifying patients with oligo-metastatic disease who could benefit from curative-intent surgical resection. Further research is needed to refine the selection criteria and optimize the treatment for this subgroup of patients.

Asset Subtitle

Raymond Osarogiagbon

Meta Tag

Speaker Raymond Osarogiagbon

Topic Metastatic NSCLC: Local Therapies - Effects

Keywords

surgical treatment

stage IV non-small cell lung cancer

NSCLC

population-based cohort

prospective cohort

surgical resections

metastatic NSCLC

survival rates

site of metastasis

curative-intent surgical resection