2023 World Conference on Lung Cancer (Posters)-EP09.04. Preoperative Circulating Tumor DNA Status Predicts Pathological Response in Advanced Non-small Cell Lung Cancer

EP09.04. Preoperative Circulating Tumor DNA Status Predicts Pathological Response in Advanced Non-small Cell Lung Cancer - PDF(Slides)

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A study conducted by Rui Fu at the School of Medicine, South China University of Technology in Guangzhou suggests that the detection of preoperative circulating tumor DNA (ctDNA) in patients with advanced non-small cell lung cancer (NSCLC) who undergo surgical treatment may indicate the response to systemic therapy and predict postoperative clinical outcomes. The study enrolled 26 patients with induced oligometastatic NSCLC who received systemic therapy and underwent pulmonary tumor resection. Blood samples were collected before and after surgery, and ctDNA testing was conducted using a next-generation sequencing panel covering cancer-associated genes. The results showed that ctDNA was detected in preoperative samples as well as samples taken post-surgery. Patients with preoperative positive ctDNA had a significantly higher non-major pathologic response ratio compared to ctDNA-negative patients. By combining preoperative positive ctDNA with preoperative maximum standardized uptake value on PET/CT scans and evaluation criteria changes, the sensitivity in predicting the pathological response to systemic therapy increased to 93.8%. The study concludes that the combination of preoperative ctDNA status and PET/CT scans has the potential to predict the effectiveness of systemic therapy in patients with induced oligometastatic NSCLC. Further follow-up is being conducted to investigate the association between perioperative ctDNA and clinical outcomes in the long-term.

Asset Subtitle

Rui Fu

Meta Tag

Speaker Rui Fu

Topic Metastatic NSCLC: Local Therapies - Predictive & Prognostic Biomarkers

Keywords

ctDNA

circulating tumor DNA

non-small cell lung cancer

NSCLC

systemic therapy

postoperative clinical outcomes

pulmonary tumor resection

next-generation sequencing

cancer-associated genes

PET/CT scans